Poly (lactic-co-glycolic acid) (PLGA) is a copolymer used as drug carrier in controlled release systems as microparticles or scaffolds. Foamed structures are industrially obtained by injecting gas at temperatures above the melting point of the polymer that may promote PLGA degradation. High temperatures are avoidable in this foaming process if a polymer dissolution is used. Ethyl acetate and ethyl lactate are suitable solvents for the PLGA since the polymer is easily solubilised, is environmentally friendly and highly recommendable for medical purposes. CO₂ is proposed as antisolvent because is environmentally benign, non-flammable and non-toxic. The knowledge of the solubility of these solvents in CO₂ is essential to find the most appropriate working conditions for the foaming process. In this work, the solubility of ethyl acetate and ethyl lactate in CO₂ in the presence of different initial concentrations of PLGA has been studied at 298.15 K and at pressures up to 150 bar using a high-pressure variable volume view cell.

聚（乳酸-乙醇酸共聚物）（PLGA）是在控释系统中用作药物载体的微粒或支架共聚物。通过在高于可能促进PLGA降解的聚合物熔点的温度下注入气体来工业上获得泡沫结构。如果使用聚合物溶解，则在该发泡过程中可避免高温。乙酸乙酯和乳酸乙酯是PLGA的合适溶剂，因为该聚合物易于溶解，环境友好且高度推荐用于医疗目的。提出将CO ₂作为抗溶剂是因为其对环境无害，不易燃且无毒。这些溶剂在CO ₂中的溶解度知识找到最适合发泡工艺的工作条件至关重要。在这项工作中，已经使用高压可变体积观察池在298.15 K和最高150 bar的压力下研究了存在不同PLGA初始浓度下的乙酸乙酯和乳酸乙酯在CO ₂中的溶解度。