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Energy Trade-offs in Host Defense: Immunology Meets Physiology
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.tem.2019.08.012
Alexandre A Steiner 1 , Andrej A Romanovsky 2
Affiliation  

Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers.

中文翻译:

宿主防御中的能量权衡:免疫学与生理学相遇

宿主防御不仅依赖于杀微生物机制(抗性),还依赖于附带损害的管理(耐受性)。在这里,我们讨论了这个免疫学概念如何与生理学出生的关于感染中热代谢反应的二分法(发烧与体温过低)的理论相融合,从而产生一个超越学科障碍的免疫模型。
更新日期:2019-12-01
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