Because of heavy energy demands to maintain bone homeostasis, the skeletal system is closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose, amino acids, and fatty acids are the chief fuel sources for bone resident cells during its remodeling. Lipids, which can be mobilized from intracellular depots in the bone marrow, can be a potent source of fatty acids. Thus, while it has been suggested that adipocytes in the bone marrow act as "filler" and are detrimental to skeletal homeostasis, we propose that marrow lipids are, in fact, essential for proper bone functioning. As such, we examine the prevailing evidence regarding the storage, use, and export of lipids within the skeletal niche, including from both in vitro and in vivo model systems. We also highlight the numerous challenges that remain to fully appreciate the relationship of lipid turnover to skeletal homeostasis.

中文翻译：

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骨髓中的脂质：不断发展的观点。


由于维持骨骼稳态需要大量能量，骨骼系统通过神经元和激素介质与全身代谢密切相关。葡萄糖、氨基酸和脂肪酸是骨驻留细胞重塑过程中的主要燃料来源。脂质可以从骨髓的细胞内库中动员出来，是脂肪酸的有效来源。因此，虽然有人认为骨髓中的脂肪细胞充当“填充物”并且不利于骨骼稳态，但我们认为骨髓脂质实际上对于正常的骨功能至关重要。因此，我们研究了有关骨骼生态位内脂质的储存、使用和输出的现有证据，包括来自体外和体内模型系统的证据。我们还强调了充分理解脂质周转与骨骼稳态之间的关系仍然存在的众多挑战。