Self‐Powered Iontophoretic Transdermal Drug Delivery System Driven and Regulated by Biomechanical Motions,Advanced Functional Materials

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Self‐Powered Iontophoretic Transdermal Drug Delivery System Driven and Regulated by Biomechanical Motions
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-10-25 , DOI: 10.1002/adfm.201907378
Changsheng Wu ₁ , Peng Jiang _{1,

2} , Wei Li ₃ , Hengyu Guo ₁ , Jie Wang ₄ , Jie Chen ₁ , Mark R. Prausnitz ₃ , Zhong Lin Wang _{1,

4}

Affiliation

Transdermal drug delivery (TDD) systems with feedback control have attracted extensive research and clinical interest owing to their unique advantages of convenience, self‐administration, and safety. Here, a self‐powered wearable iontophoretic TDD system that can be driven and regulated by the energy harvested from biomechanical motions is proposed for closed‐loop motion detection and therapy. A wearable triboelectric nanogenerator (TENG) is used as the motion sensor and energy harvester that can convert biomechanical motions into electricity for iontophoresis without stored‐energy power sources, while a hydrogel‐based soft patch with side‐by‐side electrodes is designed to enable noninvasive iontophoretic TDD. Proof‐of‐concept experiments on pig skin with dyes as model drugs successfully demonstrate the feasibility of the proposed system. This work not only extends the application of TENG in the biomedical field, but may also provide a cost‐effective solution for noninvasive, electrically assisted TDD with closed‐loop sensing and treatment.

中文翻译：

由生物力学运动驱动和调节的自供电离子电渗透皮给药系统

具有反馈控制功能的透皮给药（TDD）系统由于其便利性，自我管理和安全性的独特优势而吸引了广泛的研究和临床兴趣。在此，为闭环运动检测和治疗提出了一种可通过生物力学运动中收集的能量来驱动和调节的自供电可穿戴离子电渗疗法TDD系统。可穿戴式摩擦电纳米发生器（TENG）用作运动传感器和能量收集器，可将生物机械运动转化为电进行离子电渗疗法而无需存储能源，而带有并排电极的基于水凝胶的软贴片旨在实现无创离子电渗疗法TDD。以染料为模型药物的猪皮概念验证实验成功证明了该系统的可行性。

更新日期：2020-01-17

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