The role of the endoplasmic reticulum (ER) in phagocytosis has been the subject of debate for over a decade. Proteomic determinations and dynamic microscopy of live cells led to conflicting conclusions. Recent insights into the existence of a variety of membrane contact sites (MCS) may help reconcile the seemingly disparate views. Specifically, earlier results can be rationalized considering that the ER forms specialized MCS with nascent and maturing phagosomes, without undergoing fusion. The composition and function of documented ER-to-phagosome contact sites is described. In addition, we speculate about the possible existence of additional phagosomal contact sites, based on available knowledge of interactions between the ER and other endocytic compartments. The interaction between phagosomes and the ER has been the subject of debate. Earlier observations that led to the suggestion that the ER fuses with the phagosomal membrane can now be explained in the light of recent evidence that intimate contacts form between the two organelles.

中文翻译：

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噬菌体-内质网接触：接吻且不奔跑。

在吞噬作用中，内质网（ER）的作用已成为十多年来争论不休的话题。蛋白质组学测定和活细胞动态显微镜检查得出了相互矛盾的结论。最近对各种膜接触部位（MCS）存在的见解可能有助于调和看似截然不同的观点。具体而言，考虑到ER可以形成具有新生和成熟吞噬体的专门MCS，而无需进行融合，因此可以合理化更早的结果。描述了已记录的ER与吞噬体接触位点的组成和功能。此外，我们根据内质网与其他内吞区室之间相互作用的现有知识推测了其他吞噬体接触位点的可能存在。吞噬体与内质网之间的相互作用一直是争论的话题。