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Integrated regulation of the phosphatidylinositol cycle and phosphoinositide-driven lipid transport at ER-PM contact sites.
Traffic ( IF 3.6 ) Pub Date : 2019-12-25 , DOI: 10.1111/tra.12709 Joshua G Pemberton 1 , Yeun Ju Kim 1 , Tamas Balla 1
Traffic ( IF 3.6 ) Pub Date : 2019-12-25 , DOI: 10.1111/tra.12709 Joshua G Pemberton 1 , Yeun Ju Kim 1 , Tamas Balla 1
Affiliation
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Among the structural phospholipids that form the bulk of eukaryotic cell membranes, phosphatidylinositol (PtdIns) is unique in that it also serves as the common precursor for low-abundance regulatory lipids, collectively referred to as polyphosphoinositides (PPIn). The metabolic turnover of PPIn species has received immense attention because of the essential functions of these lipids as universal regulators of membrane biology and their dysregulation in numerous human pathologies. The diverse functions of PPIn lipids occur, in part, by orchestrating the spatial organization and conformational dynamics of peripheral or integral membrane proteins within defined subcellular compartments. The emerging role of stable contact sites between adjacent membranes as specialized platforms for the coordinate control of ion exchange, cytoskeletal dynamics, and lipid transport has also revealed important new roles for PPIn species. In this review, we highlight the importance of membrane contact sites formed between the endoplasmic reticulum (ER) and plasma membrane (PM) for the integrated regulation of PPIn metabolism within the PM. Special emphasis will be placed on non-vesicular lipid transport during control of the PtdIns biosynthetic cycle as well as toward balancing the turnover of the signaling PPIn species that define PM identity.
中文翻译：
ER-PM接触位点的磷脂酰肌醇循环和磷脂酰肌醇驱动的脂质转运的综合调控。
在构成大部分真核细胞膜的结构性磷脂中，磷脂酰肌醇（PtdIns）的独特之处在于，它还可以作为低丰度调节脂质的统称前体，统称为聚磷酸肌醇（PPIn）。PPIn物种的代谢转换受到了极大的关注，因为这些脂质作为膜生物学的通用调节剂的基本功能及其在许多人类病理学中的失调。PPIn脂质的多种功能部分是通过协调定义的亚细胞区室中外围或整合膜蛋白的空间组织和构象动力学而实现的。相邻膜之间的稳定接触位点的出现作为协调控制离子交换，细胞骨架动力学的专门平台，脂质转运还揭示了PPIn物种的重要新作用。在这篇综述中，我们强调了内质网（ER）和质膜（PM）之间形成的膜接触部位对于PM中PPIn代谢的整合调节的重要性。在控制PtdIns生物合成循环过程中，将特别着重于非囊泡脂质运输，以及平衡定义PM身份的信号PPIn物种的周转。
更新日期：2020-01-21
中文翻译：
ER-PM接触位点的磷脂酰肌醇循环和磷脂酰肌醇驱动的脂质转运的综合调控。
在构成大部分真核细胞膜的结构性磷脂中，磷脂酰肌醇（PtdIns）的独特之处在于，它还可以作为低丰度调节脂质的统称前体，统称为聚磷酸肌醇（PPIn）。PPIn物种的代谢转换受到了极大的关注，因为这些脂质作为膜生物学的通用调节剂的基本功能及其在许多人类病理学中的失调。PPIn脂质的多种功能部分是通过协调定义的亚细胞区室中外围或整合膜蛋白的空间组织和构象动力学而实现的。相邻膜之间的稳定接触位点的出现作为协调控制离子交换，细胞骨架动力学的专门平台，脂质转运还揭示了PPIn物种的重要新作用。在这篇综述中，我们强调了内质网（ER）和质膜（PM）之间形成的膜接触部位对于PM中PPIn代谢的整合调节的重要性。在控制PtdIns生物合成循环过程中，将特别着重于非囊泡脂质运输，以及平衡定义PM身份的信号PPIn物种的周转。
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