Abstract Aromatic amines found in tobacco smoke are carcinogenic to humans. There are no doubts that they cause of cancers in the lungs, bladder, kidneys, pancreas, esophagus, larynx, pharynx, and oral cavities associated with public health. Therefore, monitoring, control, and awareness toward the smoking effects are important subjects to be conveyed. Thus, rapid, sensitive, simple and accurate analytical methods for the identification of aromatic amines and their metabolites are required to provide a clear and complete visualization for the occurrence of aromatic amines by investigating the urine of smokers and nonsmokers. This comprehensive review serves to give an overview of the previous and recent studies about the analytical trends for the determination of urinary aromatic amines. This review covers the sampling methodologies and sample preparation techniques such as solvent extraction, solid phase extraction, magnetic solid phase extraction, and solid phase microextraction couple with different separation methods including gas chromatography and liquid chromatography. To add more value to this review paper, the advantages, disadvantages, challenges, and the future prospects of these methods are discussed as well. This review is hopefully beneficial for researchers to access and monitor the level of potentially carcinogenic aromatic amines in human urine.

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使用萃取和色谱分析法测定尿液中的芳香胺：小型综述

摘要 烟草烟雾中的芳香胺对人类有致癌作用。毫无疑问，它们会导致与公共卫生相关的肺癌、膀胱癌、肾癌、胰腺癌、食道癌、喉癌、咽癌和口腔癌。因此，对吸烟影响的监测、控制和认识是要传达的重要主题。因此，需要使用快速、灵敏、简单和准确的分析方法来鉴定芳香胺及其代谢物，通过调查吸烟者和非吸烟者的尿液，为芳香胺的存在提供清晰、完整的可视化。这篇综合综述旨在概述以往和最近关于尿芳香胺测定分析趋势的研究。这篇综述涵盖了采样方法和样品制备技术，如溶剂萃取、固相萃取、磁性固相萃取和固相微萃取以及不同的分离方法，包括气相色谱和液相色谱。为了增加这篇综述论文的价值，还讨论了这些方法的优点、缺点、挑战和未来前景。该综述有望有益于研究人员获取和监测人类尿液中潜在致癌芳香胺的水平。还讨论了这些方法的优点、缺点、挑战和未来前景。该综述有望有益于研究人员获取和监测人类尿液中潜在致癌芳香胺的水平。还讨论了这些方法的优点、缺点、挑战和未来前景。该综述有望有益于研究人员获取和监测人类尿液中潜在致癌芳香胺的水平。