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Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells: Concise review
STEM CELLS ( IF 4.0 ) Pub Date : 2019-10-31 , DOI: 10.1002/stem.3101 Malini Visweswaran 1 , Frank Arfuso 1 , Sudha Warrier 2 , Arun Dharmarajan 1, 3
STEM CELLS ( IF 4.0 ) Pub Date : 2019-10-31 , DOI: 10.1002/stem.3101 Malini Visweswaran 1 , Frank Arfuso 1 , Sudha Warrier 2 , Arun Dharmarajan 1, 3
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Emerging evidence in cancer metabolomics has identified reprogrammed metabolic pathways to be a major hallmark of cancer, among which deregulated lipid metabolism is a prominent field receiving increasing attention. Cancer stem cells (CSCs) comprise <0.1% of the tumor bulk and possess high self‐renewal, tumor‐initiating properties, and are responsible for therapeutic resistance, disease recurrence, and tumor metastasis. Hence, it is imperative to understand the metabolic rewiring occurring in CSCs, especially their lipid metabolism, on which there have been recent reports. CSCs rely highly upon lipid metabolism for maintaining their stemness properties and fulfilling their biomass and energy demands, ultimately leading to cancer growth and invasion. Hence, in this review we will shed light on the aberrant lipid metabolism that CSCs exploit to boost their survival, which comprises upregulation in de novo lipogenesis, lipid droplet synthesis, lipid desaturation, and β‐oxidation. Furthermore, the metabolic regulators involved in the process, such as key lipogenic enzymes, are also highlighted. Finally, we also summarize the therapeutic strategies targeting the key regulators involved in CSCs' lipid metabolism, which thereby demonstrates the potential to develop powerful and novel therapeutics against the CSC lipid metabolome.
中文翻译：
异常脂质代谢作为靶向癌症干细胞的新兴治疗策略：简明综述
癌症代谢组学的新证据表明，重新编程的代谢途径是癌症的一个主要标志，其中脂质代谢失调是一个受到越来越多关注的突出领域。癌症干细胞 (CSC) 占肿瘤体积的 <0.1%，具有高度的自我更新、肿瘤启动特性，并且负责治疗抵抗、疾病复发和肿瘤转移。因此，必须了解 CSC 中发生的代谢重新布线，尤其是它们的脂质代谢，最近有相关报道。CSC 高度依赖脂质代谢来维持其干性特性并满足其生物量和能量需求，最终导致癌症生长和侵袭。因此，在这篇综述中，我们将阐明 CSCs 用来促进其存活的异常脂质代谢，包括从头脂肪生成、脂滴合成、脂质去饱和和 β-氧化的上调。此外，还强调了该过程中涉及的代谢调节剂，例如关键的脂肪生成酶。最后，我们还总结了针对参与 CSC 脂质代谢的关键调节因子的治疗策略，从而证明了开发针对 CSC 脂质代谢组的强大而新颖的疗法的潜力。
更新日期：2019-10-31
中文翻译：
异常脂质代谢作为靶向癌症干细胞的新兴治疗策略：简明综述
癌症代谢组学的新证据表明，重新编程的代谢途径是癌症的一个主要标志，其中脂质代谢失调是一个受到越来越多关注的突出领域。癌症干细胞 (CSC) 占肿瘤体积的 <0.1%，具有高度的自我更新、肿瘤启动特性，并且负责治疗抵抗、疾病复发和肿瘤转移。因此，必须了解 CSC 中发生的代谢重新布线，尤其是它们的脂质代谢，最近有相关报道。CSC 高度依赖脂质代谢来维持其干性特性并满足其生物量和能量需求，最终导致癌症生长和侵袭。因此，在这篇综述中，我们将阐明 CSCs 用来促进其存活的异常脂质代谢，包括从头脂肪生成、脂滴合成、脂质去饱和和 β-氧化的上调。此外，还强调了该过程中涉及的代谢调节剂，例如关键的脂肪生成酶。最后，我们还总结了针对参与 CSC 脂质代谢的关键调节因子的治疗策略，从而证明了开发针对 CSC 脂质代谢组的强大而新颖的疗法的潜力。
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