To investigate the relationship between insulin resistance indices ["Revised quantitative insulin sensitivity check index" (RQUICKI; RQ), "Revised quantitative insulin sensitivity check index - β-hydroxybutyrate" (RQUICKIBHB ; RQBHB ), and "Homeostasis model assessment-insulin resistance" (HOMA-IR; HR)], and metabolic parameters in dams during late gestation, and their newborn calves. Blood was sampled twice weekly during the experimental period in 30 dry Holstein cows. In calves, blood sampling and body weight measurements were performed immediately after birth, and in 1-week-old male calves, liver and muscle biopsy samples were obtained for determining metabolic factor mRNA levels. RQ and RQBHB were negatively correlated with insulin, nonesterified fatty acid, BHB, and albumin and were positively correlated with leptin levels in blood during late gestation (p < .05). RQ, rather than RQBHB , reflected metabolism of dams, while stronger positive correlations were present between HR and blood insulin concentrations than other parameters, and calves of dams with high HR had low body weight, and high liver and muscle expression of growth hormone and insulin receptor mRNA (p < .05). RQ and HR of dams during late gestation could serve as indicators of dam metabolism and predictors of metabolism in newborn calves respectively.

中文翻译：

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胰岛素抵抗：奶牛妊娠后期指标与新生儿代谢影响之间的关系。

研究胰岛素抵抗指数[“修订的定量胰岛素敏感性检查指数”（RQUICKI; RQ），“修订的定量胰岛素敏感性检查指数-β-羟基丁酸酯”（RQUICKIBHB; RQBHB）和“稳态模型评估-胰岛素抵抗”之间的关系。 （HOMA-IR; HR）]，以及妊娠后期大坝及其新生犊牛的代谢参数。在实验期间，每周在30头干燥的荷斯坦奶牛中抽取两次血液。在小牛中，出生后立即进行血液采样和体重测量，在1周龄的雄性小牛中，获得肝脏和肌肉活检样本以确定代谢因子mRNA水平。RQ和RQBHB与胰岛素，非酯化脂肪酸，BHB，和白蛋白，并与妊娠后期血液中的瘦素水平呈正相关（p <.05）。RQ而非RQBHB反映了大坝的代谢，而HR和血液胰岛素浓度之间的正相关性高于其他参数，高HR的大坝的犊牛体重低，生长激素和胰岛素的肝脏和肌肉表达高受体mRNA（p <.05）。妊娠后期大坝的RQ和HR可以分别作为新生牛犊大坝代谢的指标和代谢指标。肝和肌肉中生长激素和胰岛素受体mRNA的高表达（p <.05）。妊娠后期大坝的RQ和HR可以分别作为新生牛犊大坝代谢的指标和代谢指标。肝和肌肉中生长激素和胰岛素受体mRNA的高表达（p <.05）。妊娠后期大坝的RQ和HR可以分别作为新生牛犊大坝代谢的指标和代谢指标。