Staphylococcus aureus interacts with the human immune system through the production of secreted factors. Key among these is protein A, a B-cell superantigen capable of interacting with both antibody Fc and VH regions. Here, we review structural and molecular features of this important example of naturally occurring bacterial superantigens, as well as engineered variants and their application in biotechnology.

中文翻译：

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蛋白质A超抗原：抗体识别的结构，工程和分子基础。

金黄色葡萄球菌通过分泌因子的产生与人类免疫系统相互作用。其中的关键是蛋白A，一种能够与抗体Fc和VH区域相互作用的B细胞超抗原。在这里，我们回顾了自然存在的细菌超抗原这一重要实例的结构和分子特征，以及工程变体及其在生物技术中的应用。