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Coordinative unsaturated CuI entities are crucial intermediates governing cell internalization of copper. A combined experimental ESI-MS and DFT study.
Metallomics ( IF 2.9 ) Pub Date : 2019-10-23 , DOI: 10.1039/c9mt00236g
Silvia Carlotto 1 , Arkadiusz Bonna 2 , Karolina Bossak-Ahmad 3 , Wojciech Bal 3 , Marina Porchia 4 , Maurizio Casarin 1 , Francesco Tisato 4
Affiliation  

Model peptides relevant to hCtr1 transchelate CuI from the anti-tumour [CuI(PTA)4]+ complex before metal internalization into tumor cells. ESI(+)MS experiments corroborated by DFT calculations indicate that tetracoordinated-CuII and linear-CuI arrangements of in situ generated copper-peptide products play a crucial role in promoting the transfer of copper from the terminal MDH portion into adjacent HSH peptide sequence.

中文翻译:

配位不饱和CuI实体是控制铜单元内部化的关键中间体。结合实验性ESI-MS和DFT研究。

在金属内化进入肿瘤细胞之前,从抗肿瘤[CuI(PTA)4 ] +复合物中与hCtr1转螯合CuI相关的模型肽。DFT计算证实的ESI(+)MS实验表明,原位生成的铜肽产物的四配位Cu II和线性Cu I排列在促进铜从MDH末端部分转移到相邻的HSH肽序列中起着至关重要的作用。
更新日期:2019-10-23
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