New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures,Alzheimer's & Dementia

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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.jalz.2019.06.4956
Adam L Boxer ₁ , Michael Gold ₂ , Howard Feldman ₃ , Bradley F Boeve ₄ , Susan L-J Dickinson ₅ , Howard Fillit ₆ , Carole Ho ₇ , Robert Paul ₈ , Rodney Pearlman ₉ , Margaret Sutherland ₁₀ , Ajay Verma ₁₁ , Stephen P Arneric ₁₂ , Brian M Alexander ₁₃ , Bradford C Dickerson ₁₄ , Earl Ray Dorsey ₁₅ , Murray Grossman ₁₆ , Edward D Huey ₁₇ , Michael C Irizarry ₁₈ , William J Marks ₁₉ , Mario Masellis _{20,

21} , Frances McFarland ₂₂ , Debra Niehoff ₅ , Chiadi U Onyike ₂₃ , Sabrina Paganoni ₂₄ , Michael A Panzara ₂₅ , Kenneth Rockwood ₂₆ , Jonathan D Rohrer ₂₇ , Howard Rosen ₁ , Robert N Schuck ₂₈ , Holly D Soares ₂₉ , Nadine Tatton ₅

Affiliation

Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Development Neurosciences, AbbVie, Chicago, IL, USA.
Department of Neurosciences, University of California San Diego, San Diego, CA, USA.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Association for Frontotemporal Degeneration, Radnor, PA, USA.
Alzheimer's Drug Discovery Foundation, New York, NY, USA.
Denali Therapeutics, San Francisco, CA, USA.
Alector, Inc., South San Francisco, CA, USA.
The Bluefield Project, San Francisco, CA, USA.
Chan Zuckerberg Initiative, Redwood City, CA, USA.
United Neuroscience, Dublin, Ireland.
Critical Path Institute, Tucson, AZ, USA.
Dana-Farber Cancer Institute, Harvard University, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Center for Health and Technology, University of Rochester, Rochester, NY, USA.
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Departments of Psychiatry and Neurology, Columbia University, NY, USA.
Formerly of Early Phase Neurosciences, Eli Lilly, Indianapolis, IN, USA.
Clinical Neurology, Verily Life Sciences, South San Francisco, CA, USA.
Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, ON, Canada.
Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
McFarland Writing, Annapolis, MD, USA.
Department Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University, Baltimore, MD, USA.
Healey Center for ALS, Massachusetts General Hospital, Boston, MA, USA.
Development, Wave Life Sciences, Boston, MA, USA.
Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada.
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK.
Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA.
Department of Neurology, AbbVie, Chicago, IL, USA.

Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.

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