Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increases metabolic rate. Brown adipose tissue (BAT) recruitment occurs during cold acclimation and includes secretion of factors, known as batokines, which target several different cell types within BAT, and promote adipogenesis, angiogenesis, immune cell interactions, and neurite outgrowth. All these processes seem to act in concert to promote an adapted BAT. Recent studies have also provided exciting data on whole body metabolic regulation with a broad spectrum of mechanisms involving BAT crosstalk with liver, skeletal muscle, and gut as well as the central nervous system. These widespread interactions might reflect the property of BAT of switching between an active thermogenic state where energy is highly consumed and drained from the circulation, and the passive thermoneutral state, where energy consumption is turned off. (Endocrine Reviews 41: XXX - XXX, 2020).

中文翻译：

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组织可塑性和人体代谢中的棕色脂肪串扰。


婴儿依靠棕色脂肪组织（BAT）作为产热的主要来源。在一些成年人中，棕色脂肪组织的残留物与中枢神经系统相邻，急性激活会增加代谢率。棕色脂肪组织 (BAT) 募集发生在冷驯化过程中，包括分泌称为 batokines 的因子，该因子针对 BAT 内的几种不同细胞类型，并促进脂肪生成、血管生成、免疫细胞相互作用和神经突生长。所有这些过程似乎协同作用，以促进适应的最佳可行技术。最近的研究还提供了有关全身代谢调节的令人兴奋的数据，其广泛的机制涉及 BAT 与肝脏、骨骼肌、肠道以及中枢神经系统的串扰。这些广泛的相互作用可能反映了 BAT 在主动产热状态（能量被高度消耗并从循环中排出）和被动热中性状态（能量消耗被关闭）之间切换的特性。 （内分泌评论 41：XXX - XXX，2020）。