Previous research has found increased home ventilation, which may affect health by altering the composition of indoor air, is associated with improvement of respiratory health, but evidence linking home ventilation to objectively measured lung function is sparse. The Colorado Home Energy Efficiency and Respiratory health (CHEER) study, a cross-sectional study of low-income, urban, nonsmoking homes across the Northern Front Range of Colorado, USA, focused on elucidating this link. We used a multipoint depressurization blower door test to measure the air tightness of the homes and calculate the annual average infiltration rate (AAIR). Lung function tests were administered to eligible participants. We analyzed data from 253 participants in 187 homes with two or more acceptable spirometry tests. We used generalized estimating equations to model forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC), and FEV₁/FVC z-scores as a function of AAIR. AAIRs ranged from 0.10 to 1.98 air changes per hour. Mean z-scores for FEV₁, FVC, and FEV₁/FVC were −0.57, 0.32, and −0.43, respectively. AAIR was positively associated with increased FEV₁/FVC z-scores, such that a 1-unit change in AAIR corresponded to a half of a standard deviation in lung function (β = 0.51, CI: 0.02–0.99). These associations were strongest for healthy populations and weaker for those with asthma and asthma-like symptoms. AAIR was not associated with FEV₁ or FVC. Our study is the first in the United States to link home ventilation by infiltration to objectively measured lung function in low-income, urban households.

先前的研究发现，增加家庭通风可能会通过改变室内空气的成分而影响健康，这与呼吸系统健康的改善有关，但将家庭通风与客观测量的肺功能联系起来的证据很少。科罗拉多家庭能源效率和呼吸健康 (CHEER) 研究是一项针对美国科罗拉多北部前线山脉低收入、城市、无烟家庭的横断面研究，重点是阐明这种联系。我们采用多点减压风门测试来测量房屋的气密性并计算年平均渗透率（AAIR）。对符合条件的参与者进行了肺功能测试。我们分析了来自 187 个家庭的 253 名参与者的数据，并进行了两项或更多可接受的肺活量测试。₁ )、用力肺活量 (FVC) 和 FEV ₁ /FVC z分数作为 AAIR 的函数。AAIR 范围为每小时 0.10 到 1.98 次换气。_{FEV 1}、FVC 和 FEV ₁ /FVC 的平均z分数分别为-0.57、0.32和-0.43。_{AAIR 与增加的 FEV 1} /FVC z分数呈正相关，因此 AAIR 的 1 个单位变化对应于肺功能标准差的一半（β  = 0.51，CI：0.02–0.99）。这些关联在健康人群中最强，在有哮喘和哮喘样症状的人群中较弱。AAIR 与 FEV _1无关或 FVC。我们的研究是美国第一个将渗透式家庭通气与客观测量的低收入城市家庭肺功能联系起来的研究。