Graphene Hybrid Anisotropic Structural Color Film for Cardiomyocytes' Monitoring,Advanced Functional Materials

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Graphene Hybrid Anisotropic Structural Color Film for Cardiomyocytes' Monitoring
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-10-22 , DOI: 10.1002/adfm.201906353
Linjie Li _{1,

2} , Zhuoyue Chen ₂ , Changmin Shao ₂ , Lingyu Sun ₂ , Lingyun Sun ₁ , Yuanjin Zhao _{1,

2}

Affiliation

Heart‐on‐a‐chip based on microfluidic platform can simulate the structure and reveal the function of heart at the micrometer level, compensating the gap between organism and experiments in vitro. In this paper, a novel heart‐on‐a‐chip system integrated with reduced graphene oxide (rGO) hybrid anisotropic structural color film is designed for cardiac sensing and evaluation. This hybrid anisotropic film is based on the opposite adhesion properties of the polyethylene glycol diacrylate (PEGDA) and gelatin methacryloyl (GelMA). The PEGDA area with low adhesion rate has inverse opal structure and specific reflection peak, while microgroove‐patterned rGO‐doped GelMA area with high adhesion rate provides the cardiomyocytes with excellent growing environment and induced orientation property. Benefiting from the design, the cultured cardiomyocytes only adhere in specific area without affecting the surface microstructure of the structural color. When cardiomyocytes recover beating, its elongation and contraction will stretch the structure of PEGDA and result in a color shift, which realizes the transformation from micromechanics to macroscopic optics. In addition, the heart‐on‐a‐chip system based on the anisotropic structural color hydrogels and microfluidics provides an outstanding visible method for cardiac sensing, which is of great significance in cardiac pathophysiological studies and drug detection in vitro.

中文翻译：

石墨烯混合各向异性结构彩色膜用于心肌细胞的监测

基于微流体平台的“心脏芯片”可以在微米水平上模拟结构并揭示心脏的功能，从而弥补生物体与体外实验之间的差距。本文设计了一种新颖的片上心脏系统，该系统与还原的氧化石墨烯（rGO）混合各向异性结构彩色膜集成在一起，用于心脏感应和评估。这种杂化各向异性薄膜基于聚乙二醇二丙烯酸酯（PEGDA）和明胶甲基丙烯酰基（GelMA）的相反粘合特性。具有低粘附率的PEGDA区域具有反蛋白石结构和特定的反射峰，而具有高粘附率的微沟槽图案rGO掺杂的GelMA区域为心肌细胞提供了极佳的生长环境和诱导的定向特性。受益于设计，培养的心肌细胞仅粘附在特定区域，而不会影响结构颜色的表面微观结构。当心肌细胞恢复搏动时，其伸长和收缩将拉伸PEGDA的结构并导致颜色变化，从而实现了从微力学到宏观光学的转变。此外，基于各向异性结构彩色水凝胶和微流控技术的片上心脏系统为心脏感应提供了一种出色的可见方法，这在心脏病理生理研究和体外药物检测中具有重要意义。实现了从微机械到宏观光学的转变。此外，基于各向异性结构彩色水凝胶和微流控技术的片上心脏系统为心脏感应提供了一种出色的可见方法，这在心脏病理生理学研究和体外药物检测中具有重要意义。实现了从微机械到宏观光学的转变。此外，基于各向异性结构彩色水凝胶和微流控技术的片上心脏系统为心脏感应提供了一种出色的可见方法，这在心脏病理生理研究和体外药物检测中具有重要意义。

更新日期：2020-01-17

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