CD34, vimentin, and vascular endothelial growth factor immunohistochemical analysis and electron microscopic tools were employed to record the initial appearance of telocytes (TCs) and stage-by-stage variations in TC localizations in the developing rabbit lung. TCs could not be identified in the primitive embryonic lung until day 18 of gestation. In the pseudoglandular lung, CD34+TCs had been recorded under the cartilage of the main bronchus, in the wall of large-sized pulmonary vessels and large epithelial tubes. In the canalicular phase, TCs could be demonstrated in the smooth muscle layer of the bronchioles including the terminal ones. The strength of CD34 immunoreactive signals had been amplified by age until the day of parturition. Ultrastructurally, TCs consisted of a tiny body and exceptionally long telopodes (Tps). The Tp consisted of alternating thin segments (podomers) and dilated ones (podoms). The Tp sometimes branched with a dichotomous pattern. TCs interconnected in a network either by homocellular junctions with neighboring TCs or by heterocellular junctions with smooth muscle cells and alveolar cells. Collectively, early detection of TCs in pulmonary vessels suggests a potential role for TCs in their angiogenesis. For the lung tissue, TCs seem to be involved in the regulation of lung histogenesis.

中文翻译：

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发育中的胎儿肺中 Telocytes 的出现和潜在意义

CD34、波形蛋白和血管内皮生长因子免疫组织化学分析和电子显微镜工具被用来记录发育中的兔肺中端粒细胞 (TC) 的初始外观和 TC 定位的阶段性变化。直到妊娠第 18 天才能在原始胚胎肺中鉴定出 TC。在假腺肺中，CD34+TCs 已记录在主支气管软骨下、大型肺血管壁和大型上皮管中。在小管期，TCs 可以在细支气管的平滑肌层中显示，包括末端的。CD34 免疫反应信号的强度随着年龄的增长而增强，直到分娩当天。在超微结构上，TCs 由一个微小的身体和异常长的端足节 (Tps) 组成。Tp 由交替的薄段（豆荚）和扩张的（豆荚）组成。Tp 有时以二分模式分枝。TCs 通过与相邻 TCs 的同细胞连接或通过与平滑肌细胞和肺泡细胞的异细胞连接在网络中相互连接。集体，肺血管中 TC 的早期检测表明 TC 在其血管生成中的潜在作用。对于肺组织，TCs 似乎参与了肺组织发生的调节。