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The non-apoptotic role of caspase-9 promotes differentiation in leukemic cells.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ( IF 4.6 ) Pub Date : 2019-08-06 , DOI: 10.1016/j.bbamcr.2019.118524 Zahra Madadi 1 , Shiva Akbari-Birgani 2 , Parviz Davoodi Monfared 1 , Saeed Mohammadi 3
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ( IF 4.6 ) Pub Date : 2019-08-06 , DOI: 10.1016/j.bbamcr.2019.118524 Zahra Madadi 1 , Shiva Akbari-Birgani 2 , Parviz Davoodi Monfared 1 , Saeed Mohammadi 3
Affiliation
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Caspase family contains cysteine proteases involving in the key cellular processes, such as apoptosis, inflammation, and autophagy. There is a growing body of evidence that caspase family also plays a role in cellular differentiation. Evidence suggests that caspase-9 is among the most important members with non-apoptotic roles in the execution of differentiation. Since drug-induced differentiation in some types of cancer cells is a promising treatment, we have investigated caspase-9 activity during differentiation of a cancer cell; leukemia. We demonstrate that caspase-9 has increased activity during differentiation and also the inhibition of caspase-9 will prevent the granulocytic differentiation of leukemic cells. In addition, we studied the differentiation induction mediated by caspase-9 using an inducible variant of caspase-9. Results indicate the caspase-9 mediated differentiation accompanied by a reduction in the expression of CD33 and an increase in CD15. Notably, all of the events occur when cell viability remains constant. Owing to the evidence, caspase-9 activity is considered as a central factor in the execution of differentiation in leukemic cells.
中文翻译：
caspase-9的非凋亡作用促进白血病细胞的分化。
Caspase家族包含半胱氨酸蛋白酶，参与关键的细胞过程，例如凋亡，炎症和自噬。越来越多的证据表明，半胱天冬酶家族在细胞分化中也起着作用。有证据表明，caspase-9是分化过程中具有非凋亡作用的最重要成员之一。由于药物诱导的某些类型癌细胞的分化是一种有前途的治疗方法，因此我们研究了癌细胞分化过程中caspase-9的活性。白血病。我们证明caspase-9在分化过程中具有增加的活性，并且对caspase-9的抑制也将阻止白血病细胞的粒细胞分化。此外，我们研究了使用caspase-9的诱导型变体，由caspase-9介导的分化诱导。结果表明，caspase-9介导的分化伴随着CD33表达的减少和CD15的增加。值得注意的是，所有事件都在细胞活力保持恒定时发生。由于有证据，caspase-9活性被认为是白血病细胞分化过程中的重要因素。
更新日期：2019-08-06
中文翻译：
caspase-9的非凋亡作用促进白血病细胞的分化。
Caspase家族包含半胱氨酸蛋白酶，参与关键的细胞过程，例如凋亡，炎症和自噬。越来越多的证据表明，半胱天冬酶家族在细胞分化中也起着作用。有证据表明，caspase-9是分化过程中具有非凋亡作用的最重要成员之一。由于药物诱导的某些类型癌细胞的分化是一种有前途的治疗方法，因此我们研究了癌细胞分化过程中caspase-9的活性。白血病。我们证明caspase-9在分化过程中具有增加的活性，并且对caspase-9的抑制也将阻止白血病细胞的粒细胞分化。此外，我们研究了使用caspase-9的诱导型变体，由caspase-9介导的分化诱导。结果表明，caspase-9介导的分化伴随着CD33表达的减少和CD15的增加。值得注意的是，所有事件都在细胞活力保持恒定时发生。由于有证据，caspase-9活性被认为是白血病细胞分化过程中的重要因素。
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