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Proteomics for understanding pathogenesis, immune modulation and host pathogen interactions in aquaculture.
Comparative Biochemistry and Physiology D: Genomics & Proteomics ( IF 2.2 ) Pub Date : 2019-09-11 , DOI: 10.1016/j.cbd.2019.100625
Fatma Ahmed 1 , Gokhlesh Kumar 2 , Faiza M Soliman 3 , Mohamed A Adly 3 , Hamdy A M Soliman 3 , Mansour El-Matbouli 2 , Mona Saleh 2
Affiliation  

Proteomic analyses techniques are considered strong tools for identifying and quantifying the protein contents in different organisms, organs and secretions. In fish biotechnology, the proteomic analyses have been used for wide range of applications such as identification of immune related proteins during infections and stresses. The proteomic approach has a significant role in understanding pathogen surviving strategies, host defence responses and subsequently, the fish pathogen interactions. Proteomic analyses were employed to highlight the virulence related proteins secreted by the pathogens to invade the fish host's defence barriers and to monitor the kinetics of protein contents of different fish organs in response to infections. The immune related proteins of fish and the virulence related proteins of pathogens are up or down regulated according to their functions in defence or pathogenesis. Therefore, the proteomic analyses are useful in understanding the virulence mechanisms of microorganisms and the fish pathogen interactions thereby supporting the development of new effective therapies. In this review, we focus and summarise the recent proteomic profiling studies exploring pathogen virulence activities and fish immune responses to stressors and infections.

中文翻译:

蛋白质组学,用于了解水产养殖中的发病机理,免疫调节和宿主病原体相互作用。

蛋白质组学分析技术被认为是鉴定和定量不同生物体,器官和分泌物中蛋白质含量的强大工具。在鱼类生物技术中,蛋白质组学分析已被广泛应用,例如在感染和压力期间鉴定免疫相关蛋白。蛋白质组学方法在理解病原体生存策略,宿主防御反应以及随后的鱼类病原体相互作用方面具有重要作用。蛋白质组学分析被用于突出病原体分泌的与毒力相关的蛋白质,以侵入鱼宿主的防御屏障,并监测不同鱼器官对感染的反应动力学。鱼的免疫相关蛋白和病原体的毒力相关蛋白根据其在防御或发病机理中的功能而被上调或下调。因此,蛋白质组学分析有助于理解微生物的毒力机制和鱼类病原体的相互作用,从而支持开发新的有效疗法。在这篇综述中,我们集中并总结了最近的蛋白质组分析研究,这些研究探索了病原体的毒力活动以及鱼类对应激源和感染的免疫反应。
更新日期:2019-09-11
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