The nervous system has been recently shown to exert impact on gastric cancer directly and indirectly. Gastric cancer cells invade nerve fibers to induce outgrowth and branching of neural cells, and nerve fibers in turn infiltrate into tumor microenvironment to promote progression of gastric cancer. Additionally, the neuro-immune interaction also plays an important role in gastric cancer development. The interplay of nerves and gastric cancer is mediated by many nervous system-associated factors, which can not only be synthesized and released by both cancer cells and nerve terminals, but also participate in regulation of many aspects of gastric cancer such as cell proliferation, angiogenesis, metastasis and recurrence. Furthermore, clinical researches indicate that some of these factors are significant diagnosis and prognosis biomarkers for gastric cancer. Herein, we reviewed recent advances and future prospects of the interaction between nervous system and gastric cancer.

中文翻译：

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神经系统和胃癌。

最近显示神经系统直接或间接对胃癌产生影响。胃癌细胞侵入神经纤维以诱导神经细胞的生长和分支，神经纤维又浸润到肿瘤微环境中以促进胃癌的进展。另外，神经-免疫相互作用在胃癌的发展中也起重要作用。神经和胃癌的相互作用是由许多神经系统相关因素介导的，不仅可以由癌细胞和神经末梢合成和释放，还可以参与胃癌许多方面的调控，例如细胞增殖，血管生成。 ，转移和复发。此外，临床研究表明，其中一些因素是胃癌的重要诊断和预后生物标志物。本文中，我们回顾了神经系统和胃癌之间相互作用的最新进展和未来前景。