Diabetic kidney disease remains the most common cause of end-stage kidney disease in the world. Despite reductions in incidence rates of myocardial infarction and stroke in people with diabetes over the past 3 decades, the risk of diabetic kidney disease has remained unchanged, and may even be increasing in younger individuals afflicted with this disease. Accordingly, changes in public health policy have to be implemented to address the root causes of diabetic kidney disease, including the rise of obesity and diabetes, in addition to the use of safe and effective pharmacological agents to prevent cardiorenal complications in people with diabetes. The aim of this article is to review the mechanisms of pathogenesis and therapies that are either in clinical practice or that are emerging in clinical development programs for potential use to treat diabetic kidney disease.

中文翻译：

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糖尿病肾脏疾病的新生物学机制和治疗意义。

糖尿病肾病仍然是世界上终末期肾病的最常见原因。尽管在过去的30年中，糖尿病患者的心肌梗塞和中风的发病率有所降低，但糖尿病性肾脏疾病的风险仍未改变，甚至在罹患该疾病的年轻个体中甚至有所增加。因此，除了使用安全有效的药物预防糖尿病人的心肾并发症外，还必须实施公共卫生政策的改变以解决糖尿病肾病的根本原因，包括肥胖和糖尿病的增加。