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Building machines with DNA molecules.
Nature Reviews Genetics ( IF 39.1 ) Pub Date : 2019-10-21 , DOI: 10.1038/s41576-019-0175-6
Hamid Ramezani 1 , Hendrik Dietz 1
Affiliation  

In nature, DNA molecules carry the hereditary information. But DNA has physical and chemical properties that make it attractive for uses beyond heredity. In this Review, we discuss the potential of DNA for creating machines that are both encoded by and built from DNA molecules. We review the main methods of DNA nanostructure assembly, describe recent advances in building increasingly complex molecular structures and discuss strategies for creating machine-like nanostructures that can be actuated and move. We highlight opportunities for applications of custom DNA nanostructures as scientific tools to address challenges across biology, chemistry and engineering.

中文翻译:

用 DNA 分子建造机器。

在自然界中,DNA 分子携带遗传信息。但是 DNA 具有物理和化学特性,使其具有超越遗传的用途。在这篇评论中,我们讨论了 DNA 在创造由 DNA 分子编码和构建的机器方面的潜力。我们回顾了 DNA 纳米结构组装的主要方法,描述了构建日益复杂的分子结构的最新进展,并讨论了创建可以驱动和移动的类似机器的纳米结构的策略。我们强调定制 DNA 纳米结构作为科学工具的应用机会,以应对生物学、化学和工程领域的挑战。
更新日期:2019-10-21
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