Functionalization-induced self-assembly under ambient conditions via thiol-epoxide “click” chemistry†,Polymer Chemistry

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Functionalization-induced self-assembly under ambient conditions via thiol-epoxide “click” chemistry†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2019-10-21 , DOI: 10.1039/c9py01144g
David H. Howe _{1,

2,

3,

4} , Ken J. Jenewein _{1,

2,

3,

4} , James L. Hart _{1,

2,

3,

4} , Mitra L. Taheri _{1,

2,

3,

4} , Andrew J. D. Magenau _{1,

2,

3,

4}

Affiliation

Polymer micelles were formed using thiol-epoxide “click” chemistry to trigger functionalization-induced self-assembly (FISA) of block copolymers by modifying a reactive glycidyl methacrylate block with solvophobes. Ambient conditions, polymer concentrations up to 10 wt%, and an array of functional thiols were found effective for nanoparticle synthesis. Real-time analysis enabled direct observation of the self-assembly process, revealing mechanistic details and a critical degree of functionalization required for micellization.

中文翻译：

在环境条件下通过硫醇-环氧“点击”化学作用引起的自组装†

使用硫醇-环氧“点击”化学形成聚合物胶束，以通过用疏溶剂性改性反应性甲基丙烯酸缩水甘油酯嵌段来引发嵌段共聚物的官能化诱导的自组装（FISA）。发现环境条件，高达10 wt％的聚合物浓度和一系列功能性硫醇对于纳米粒子合成有效。实时分析能够直接观察自组装过程，揭示出机械细节和胶束化所需的关键功能化程度。

更新日期：2020-01-02

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