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Independent association of low IFNλ1 gene expression and type I IFN score/IFNλ1 ratio with obstetric manifestations and triple antiphospholipid antibody positivity in primary antiphospholipid syndrome.
Clinical Immunology ( IF 4.5 ) Pub Date : 2019-10-19 , DOI: 10.1016/j.clim.2019.108265
Christina-Maria Flessa 1 , Stelios Vlachiotis 2 , Adrianos Nezos 3 , Evangelos Andreakos 2 , Clio P Mavragani 4 , Maria G Tektonidou 5
Affiliation  

Recent data suggest an important role of type I interferons (IFN) in antiphospholipid syndrome (APS). Here we aimed to evaluate the interplay of type I and type III (or IFNλs) IFNs in APS and potential clinical and serological associations. Our findings suggest that patients with primary APS (PAPS) and systemic lupus erythematosus (SLE)/APS displayed increased type I IFN scores but decreased IFNλ1 gene expression levels compared to healthy individuals, as assessed with real-time qPCR analysis in isolated peripheral blood mononuclear cells (PBMCs). Type I IFN score/IFNλ1 ratio was remarkably higher in patients with PAPS and SLE/APS as well as in SLE patients with or without antiphospholipid antibodies (aPL) vs controls. In conclusion, our results reveal an association between low IFNλ1 expression and obstetric APS. Moreover, the type I IFN score/IFNλ1 ratio seems to be a potential marker of high risk APS given its associations with triple aPL positivity.

中文翻译:


低 IFNλ1 基因表达和 I 型 IFN 评分/IFNλ1 比率与原发性抗磷脂综合征中产科表现和三联抗磷脂抗体阳性的独立关联。



最近的数据表明 I 型干扰素 (IFN) 在抗磷脂综合征 (APS) 中发挥重要作用。在这里,我们的目的是评估 I 型和 III 型(或 IFNλ)干扰素在 APS 中的相互作用以及潜在的临床和血清学关联。我们的研究结果表明,通过对分离的外周血单核细胞进行实时 qPCR 分析进行评估,与健康个体相比,原发性 APS (PAPS) 和系统性红斑狼疮 (SLE)/APS 患者的 I 型 IFN 评分升高,但 IFNλ1 基因表达水平降低细胞(PBMC)。与对照组相比,PAPS 和 SLE/APS 患者以及有或没有抗磷脂抗体 (aPL) 的 SLE 患者的 I 型 IFN 评分/IFNλ1 比率显着较高。总之,我们的结果揭示了 IFNλ1 低表达与产科 APS 之间的关联。此外,I 型 IFN 评分/IFNλ1 比率似乎是高风险 APS 的潜在标志,因为它与三重 aPL 阳性相关。
更新日期:2019-10-19
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