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Polysaccharide-containing block copolymers: synthesis and applications
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2019-10-18 , DOI: 10.1039/c9qm00481e
Anastasia S. Volokhova 1, 2, 3, 4, 5 , Kevin J. Edgar 2, 3, 4, 5, 6 , John B. Matson 1, 2, 3, 4, 5
Affiliation  

Polysaccharide-based block copolymers have been studied since the early 1960s and command growing interest due to the increasing importance of sustainable materials. Polysaccharides are renewable, often biodegradable, generally nontoxic, and offer wide structural variety, yielding remarkably diverse materials that provide a wide range of properties and applications. Block copolymers containing one or more polysaccharide blocks and one or more synthetic blocks can be synthesized using a variety of methods, either through direct coupling or chain extension approaches. Here we review current synthetic methods for the preparation of polysaccharide-containing block copolymers. We also discuss established and emerging applications of this class of block copolymers, such as their use as drug delivery vehicles, hydrogels for localized drug delivery, and surfactants/interfacial agents for stabilizing interfaces, including those in polysaccharide/synthetic polymer blends.

中文翻译:

含多糖的嵌段共聚物:合成与应用

自1960年代初以来,一直在研究基于多糖的嵌段共聚物,并且由于可持续材料的重要性日益提高,因此引起了越来越多的关注。多糖是可再生的,通常是可生物降解的,通常是无毒的,并提供了广泛的结构多样性,产生了非常多样化的材料,这些材料提供了广泛的特性和应用。包含一种或多种多糖嵌段和一种或多种合成嵌段的嵌段共聚物可以使用多种方法,通过直接偶联或扩链方法来合成。在这里,我们回顾了目前制备含多糖嵌段共聚物的合成方法。我们还将讨论这类嵌段共聚物的已建立和正在出现的应用,例如它们用作药物传递载体,用于局部药物传递的水凝胶,
更新日期:2019-12-19
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