Remove, Recycle, Degrade: Regulating Plasma Membrane Protein Accumulation.,The Plant Cell

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Remove, Recycle, Degrade: Regulating Plasma Membrane Protein Accumulation.
The Plant Cell ( IF 10.0 ) Pub Date : 2019-10-18 , DOI: 10.1105/tpc.19.00433
Cecilia Rodriguez-Furlan ₁ , Elena A Minina _{2,

3} , Glenn R Hicks _{2,

4}

Affiliation

Interactions between plant cells and the environment rely on modulation of protein receptors, transporters, channels, and lipids at the plasma membrane (PM) to facilitate intercellular communication, nutrient uptake, environmental sensing, and directional growth. These functions are fine-tuned by cellular pathways maintaining or reducing particular proteins at the PM. Proteins are endocytosed, and their fate is decided between recycling and degradation to modulate localization, abundance, and activity. Selective autophagy is another pathway regulating PM protein accumulation in response to specific conditions or developmental signals. The mechanisms regulating recycling, degradation, and autophagy have been studied extensively, yet we are just now addressing their regulation and coordination. Here, we (1) provide context concerning regulation of protein accumulation, recycling, or degradation by overviewing endomembrane trafficking; (2) discuss pathways regulating recycling and degradation in terms of cellular roles and cargoes; (3) review plant selective autophagy and its physiological significance; (4) focus on two decision-making mechanisms: regulation of recycling versus degradation of PM proteins and coordination between autophagy and vacuolar degradation; and (5) identify future challenges.

中文翻译：

去除、回收、降解：调节质膜蛋白积累。

植物细胞与环境之间的相互作用依赖于质膜 (PM) 上蛋白质受体、转运蛋白、通道和脂质的调节，以促进细胞间通讯、营养吸收、环境感知和定向生长。这些功能通过维持或减少 PM 特定蛋白质的细胞途径进行微调。蛋白质被内吞，它们的命运取决于回收和降解，以调节定位、丰度和活性。选择性自噬是响应特定条件或发育信号而调节 PM 蛋白积累的另一种途径。调节回收、降解和自噬的机制已被广泛研究，但我们现在才解决它们的调节和协调问题。在这里，我们（1）通过概述内膜运输提供有关蛋白质积累、回收或降解调节的背景信息；（2）讨论细胞作用和货物方面调节回收和降解的途径； (3)综述植物选择性自噬及其生理意义；（4）关注两个决策机制：PM蛋白回收与降解的调节以及自噬与液泡降解之间的协调； (5) 确定未来的挑战。

更新日期：2019-12-11

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