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Advances in Enantioselective Construction of Trifluoromethoxylated Stereogenic Carbon Centers
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2019-12-09 , DOI: 10.1002/cjoc.201900374
Xiaohuan Jiang 1 , Pingping Tang 1
Affiliation  

In recent years, the trifluoromethoxy (OCF3) functional group has received extensive attention in pharmaceuticals, agrochemicals and material sciences. However, the methods for the enantioselective synthesis of trifluoromethoxylated stereogenic carbon centers are rare owing to the nature of easy decomposition of OCF3 anion and limited OCF3 reagent. And the asymmetric trifluoromethoxylation will be a hot research topic in near future due to the unique biological properties of a single isomer. This article mainly focuses on the recent advances in the enantioselective construction of trifluoromethoxylated stereogenic carbon centers.image

中文翻译:

三氟甲氧基化立体碳中心的对映选择性建设进展

近年来,三氟甲氧基(OCF 3)官能团在制药,农业化学和材料科学领域受到了广泛关注。然而,由于容易分解OCF 3阴离子和限制OCF 3试剂的性质,用于三氟甲氧基化的立体碳中心的对映选择性合成的方法很少。由于单一异构体的独特生物学特性,不对称三氟甲氧基化将在不久的将来成为热门研究课题。本文主要关注三氟甲氧基化的立体碳中心的对映选择性构建的最新进展。图像
更新日期:2019-12-09
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