CD8+ Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4+ Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8+ and CD4+ Tregs, and we will discuss the biology, development and induction of CD8+ Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.

中文翻译：

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CD8 +调节性T细胞在免疫耐受方面的未来前景。

与传统的CD4 + Tregs相比，CD8 + Tregs的表型，功能机制和抑制能力已有长足的描述，并且取得了重大进展。他们现在处于临床使用的曙光中。在这篇综述中，我们将总结它们的表型特征，作用机制，CD8 +和CD4 + Treg之间的相似性，差异和协同作用，并讨论CD8 + Treg的生物学特性，开发和诱导作用，其临床生产，考虑开放性。问题/不确定性以及未来的技术上可获得的改进，尤其是通过基因改造。