Regulatory T cells (Treg) have proven to be a powerful immunologic force in nearly every organ system and hold therapeutic potential for a wide range of diseases. Insights gained from non-transplant pathologies, such as infection, cancer, and autoimmunity, are now being translated to the field of solid organ transplantation, particularly for livers and kidneys. Recent insights from animal models of lung transplantation have established that Tregs play a vital role in suppressing rejection and facilitating tolerance of lung allografts, and such discoveries are being validated in human studies and preclinical trials. Given that long-term outcomes following lung transplantation remain profoundly limited by chronic rejection, Treg therapy holds the potential to significantly improve patient outcomes and should be aggressively investigated.

中文翻译：

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肺移植后调节性 T 细胞的新兴作用。

调节性 T 细胞 (Treg) 已被证明是几乎所有器官系统中的强大免疫力量，并具有治疗多种疾病的潜力。从非移植病理学中获得的见解，如感染、癌症和自身免疫，现在正在转化为实体器官移植领域，尤其是肝脏和肾脏。最近来自肺移植动物模型的见解已经确定，Tregs 在抑制排斥和促进肺同种异体移植物的耐受性方面起着至关重要的作用，并且这些发现正在人体研究和临床前试验中得到验证。鉴于肺移植后的长期结果仍然受到慢性排斥的严重限制，Treg 治疗有可能显着改善患者的结果，应该积极研究。