Predicting the orientation of magnetic microgel rods for soft anisotropic biomimetic hydrogels†,Polymer Chemistry

当前位置： X-MOL 学术 › Polym. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Predicting the orientation of magnetic microgel rods for soft anisotropic biomimetic hydrogels†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2019-10-18 , DOI: 10.1039/c9py01008d
Jonas C. Rose _{1,

2,

3} , Maaike Fölster _{1,

2,

3} , Lukas Kivilip _{2,

3,

4,

5} , Jose L. Gerardo-Nava _{1,

2,

3} , Esther E. Jaekel _{1,

2,

3} , David B. Gehlen _{1,

2,

3} , Wilko Rohlfs _{2,

3,

4,

5} , Laura De Laporte _{1,

2,

3,

4,

6}

Affiliation

Living multicellular organisms comprise a high degree of soft anisotropic tissues but the development of controlled artificial assembly processes to mimic them remains challenging. Therefore, injectable, polymeric, magneto-responsive microgel rods are fabricated to orient within a low magnetic field. The incorporated superparamagnetic nanoparticles induce local dipole moments, resulting in a total magnetic torque that endows microgels with different structural, mechanical, and biochemical properties. In this report, a predictive macroscopic model based on an ellipsoidal element dispersed in a Newtonian fluid is adjusted using experimental data, which enables the prediction of the orientation rate and the required magnetic field strength for various microgel design parameters and fluid viscosities. The ordered microgels are fixed by crosslinking of a surrounding hydrogel, and can be employed for a wide variety of applications where anisotropic composite hydrogels play a crucial role; for instance as adaptive materials or in biomedical applications, wherein the model predictions can reduce animal experiments.

中文翻译：

预测软各向异性仿生水凝胶的磁性微凝胶棒的取向†

活的多细胞生物包含高度柔软的各向异性组织，但模仿它们的受控人工组装过程的发展仍然具有挑战性。因此，可注射的，聚合的，磁响应的微凝胶棒被制造为在低磁场中定向。掺入的超顺磁性纳米粒子会引起局部偶极矩，从而产生总磁转矩，从而赋予微凝胶不同的结构，机械和生化特性。在本报告中，使用实验数据调整了基于分散在牛顿流体中的椭圆体元素的预测宏观模型，该模型能够预测取向速率以及各种微凝胶设计参数和流体粘度所需的磁场强度。有序的微凝胶通过周围水凝胶的交联而固定，可用于各向异性复合水凝胶起关键作用的多种应用。例如作为适应性材料或在生物医学应用中，其中模型预测可以减少动物实验。

更新日期：2020-01-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11