Effect of efflux pump inhibitors on the susceptibility of Mycobacterium avium complex to clarithromycin.,The Journal of Antibiotics

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Effect of efflux pump inhibitors on the susceptibility of Mycobacterium avium complex to clarithromycin.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-10-17 , DOI: 10.1038/s41429-019-0245-1
Melissa Menichini ₁ , Nicoletta Lari ₁ , Laura Rindi ₁

Affiliation

In this study we aimed to evaluate the effect of the combination of clarithromycin and four inhibitors of efflux pumps (EPIs), including berberine (BER), carbonyl cyanide m-chlorophenylhydrazone (CCCP), piperine (PIP) and tetrandrine (TET), against 12 Mycobacterium avium complex clinical isolates. The minimum inhibitory concentration (MIC) of clarithromycin showed at least a fourfold reduction in presence of BER (83% of total isolates), CCCP (67%), PIP (25%) and TET (75%). Our results showed that the EPIs tested are active against both clarithromycin susceptible and resistant isolates. In particular, among the six resistant isolates, TET reversed the resistance phenotype of three strains, BER of two strains, and CCCP and PIP of one strain. Overall, our findings show the importance of these compounds in increasing the efficacy of clarithromycin in MAC clinical isolates.

中文翻译：

外排泵抑制剂对鸟分枝杆菌复合物对克拉霉素敏感性的影响。

在这项研究中，我们旨在评估克拉霉素和四种外排泵抑制剂（包括小ber碱（BER），羰基氰化物间氯苯hydr（CCCP），胡椒碱（PIP）和粉防己碱（TET））的联合作用。 12鸟分枝杆菌复杂的临床分离株。在BER（占分离菌总数的83％），CCCP（占67％），PIP（占25％）和TET（占75％）的情况下，克拉霉素的最低抑菌浓度（MIC）至少降低了四倍。我们的结果表明，所测试的EPI对克拉霉素易感和耐药菌株均具有活性。特别是，在这六个抗性分离株中，TET逆转了三个菌株的抗性表型，两个菌株的BER和一个菌株的CCCP和PIP。全面的，

更新日期：2020-01-16

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