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Production of foetal globin in adult monkeys.
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2019-11-01 , DOI: 10.1038/s41551-019-0475-3
Daniel E Bauer 1, 2, 3, 4, 5
Affiliation  

Haematopoietic stem and progenitor cells, edited via CRISPR to mimic mutations ameliorating sickle-cell disease, engraft when transplanted in macaques and maintain foetal haemoglobin in circulation.

中文翻译:

成年猴中胎儿珠蛋白的产生。

通过CRISPR编辑的造血干细胞和祖细胞可模拟缓解镰状细胞疾病的突变,移植到猕猴中后可植入并维持胎儿血红蛋白循环。
更新日期:2019-10-17
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