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Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2019-10-17 , DOI: 10.1038/s41372-019-0505-8 Martha Scott Tomlinson 1 , Hudson P Santos 2 , Jill R Stewart 1 , Robert Joseph 3 , Alan Leviton 4 , Andrew B Onderdonk 5 , Karl C K Kuban 6 , Timothy Heeren 7 , T Michael O'Shea 8 , Rebecca C Fry 1 ,
Journal of Perinatology ( IF 2.4 ) Pub Date : 2019-10-17 , DOI: 10.1038/s41372-019-0505-8 Martha Scott Tomlinson 1 , Hudson P Santos 2 , Jill R Stewart 1 , Robert Joseph 3 , Alan Leviton 4 , Andrew B Onderdonk 5 , Karl C K Kuban 6 , Timothy Heeren 7 , T Michael O'Shea 8 , Rebecca C Fry 1 ,
Affiliation
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OBJECTIVE
Infection of the placenta has been associated with preterm birth as well as neurocognitive impairment. This study aimed to determine whether specific bacterial species in the placenta of extremely preterm pregnancies are associated with neurological deficits later in life.
STUDY DESIGN
Using data from 807 children in the ELGAN study the risks of a low score on six neurological assessments in relation to 15 different microbes were quantified with odds ratios.
RESULTS
The presence of certain microbial species in the placenta was associated with lower scores on numerical and oral language assessments. Lactobacillus sp. was associated with decreased risk of a low oral language score and a composite measure of IQ and executive function.
CONCLUSION
Placental microorganisms were associated with neurocognitive, but not social-communicative, outcomes at age 10. In contrast, the presence of the anti-inflammatory Lactobacillus sp. in the placenta was associated with a lower risk of impaired neurocognitive functions.
中文翻译：
10 岁早产儿的神经认知和社会交流功能：与从胎盘实质中恢复的微生物的关联。
目的 胎盘感染与早产和神经认知障碍有关。本研究旨在确定极度早产的胎盘中的特定细菌种类是否与生命后期的神经缺陷有关。研究设计 在 ELGAN 研究中使用来自 807 名儿童的数据，用比值比量化了与 15 种不同微生物相关的六项神经学评估的低分风险。结果 胎盘中某些微生物种类的存在与数字和口语评估的较低分数有关。乳酸杆菌 与口语分数低的风险降低以及智商和执行功能的综合测量有关。结论 胎盘微生物与神经认知有关，但与社会交流无关，10 岁时的结果。相比之下，抗炎乳杆菌属的存在。在胎盘中与神经认知功能受损的风险较低有关。
更新日期：2019-10-17
中文翻译：
10 岁早产儿的神经认知和社会交流功能：与从胎盘实质中恢复的微生物的关联。
目的 胎盘感染与早产和神经认知障碍有关。本研究旨在确定极度早产的胎盘中的特定细菌种类是否与生命后期的神经缺陷有关。研究设计 在 ELGAN 研究中使用来自 807 名儿童的数据，用比值比量化了与 15 种不同微生物相关的六项神经学评估的低分风险。结果 胎盘中某些微生物种类的存在与数字和口语评估的较低分数有关。乳酸杆菌 与口语分数低的风险降低以及智商和执行功能的综合测量有关。结论 胎盘微生物与神经认知有关，但与社会交流无关，10 岁时的结果。相比之下，抗炎乳杆菌属的存在。在胎盘中与神经认知功能受损的风险较低有关。
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