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Effects of white-coat, masked and sustained hypertension on coronary artery stenosis and cardiac arrhythmia
Hypertension Research ( IF 4.3 ) Pub Date : 2019-10-17 , DOI: 10.1038/s41440-019-0342-3 Peng Cai 1 , Weitian Zhong 1 , Yan Wang 2 , Xukai Wang 1
Hypertension Research ( IF 4.3 ) Pub Date : 2019-10-17 , DOI: 10.1038/s41440-019-0342-3 Peng Cai 1 , Weitian Zhong 1 , Yan Wang 2 , Xukai Wang 1
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This study aimed to investigate whether hypertension phenotypes such as white-coat hypertension (WCHT), diagnosed with the addition of nighttime blood pressure (BP) criteria, are related to coronary artery stenosis (CAS) and cardiac arrhythmia. In this cross-sectional observational study, 844 participants who did not use antihypertensive, lipid-lowering, and antiplatelet drugs were selected. The subjects were divided into normotensive (NT), WCHT, masked hypertension (MHT), and sustained hypertension (SHT) groups based on the results of clinic BP measurement and ambulatory BP monitoring. Coronary angiography and ambulatory electrocardiography were performed to determine the participants’ CAS and cardiac arrhythmia status. Coronary angiography revealed 556 patients with CAS and 288 participants with normal coronary arteries. The chi-squared test showed that the incidence of CAS was higher in the MHT and SHT groups than in the NT group, while no significant change was found in the WCHT group ( P = 0.003, P < 0.001, P = 0.119). The logarithm of the Gensini score was used to compare the degree of CAS between the groups. Multiple linear regression analysis showed that the degree of CAS was higher in the WCHT, MHT, and SHT groups than in the NT group ( P < 0.05). The incidences of frequent atrial premature beats, atrial tachycardia, and ventricular cardiac arrhythmia were significantly higher in the WCHT and SHT groups than in the NT group, while only ventricular cardiac arrhythmia changes were observed in the MHT group. This study found that hypertension phenotypes such as WCHT were closely associated with CAS and cardiac arrhythmia.
中文翻译：
白大衣、隐匿性和持续性高血压对冠状动脉狭窄和心律失常的影响
本研究旨在调查白大衣高血压（WCHT）等高血压表型（加上夜间血压（BP）标准诊断）是否与冠状动脉狭窄（CAS）和心律失常相关。在这项横断面观察性研究中，选择了 844 名未使用抗高血压、降脂和抗血小板药物的参与者。根据临床血压测量和动态血压监测结果将受试者分为正常血压（NT）组、WCHT组、隐匿性高血压（MHT）组和持续性高血压（SHT）组。进行冠状动脉造影和动态心电图以确定参与者的 CAS 和心律失常状态。冠状动脉造影显示 556 名 CAS 患者和 288 名参与者冠状动脉正常。卡方检验显示，MHT 和 SHT 组 CAS 发生率高于 NT 组，而 WCHT 组无明显变化（ P = 0.003、P < 0.001、P = 0.119）。采用Gensini评分的对数来比较各组之间的CAS程度。多元线性回归分析显示，WCHT、MHT、SHT 组 CAS 程度高于 NT 组（ P < 0.05）。WCHT和SHT组频繁房性早搏、房性心动过速和室性心律失常的发生率显着高于NT组，而MHT组仅观察到室性心律失常改变。本研究发现WCHT等高血压表型与CAS和心律失常密切相关。
更新日期：2019-10-17
中文翻译：
白大衣、隐匿性和持续性高血压对冠状动脉狭窄和心律失常的影响
本研究旨在调查白大衣高血压（WCHT）等高血压表型（加上夜间血压（BP）标准诊断）是否与冠状动脉狭窄（CAS）和心律失常相关。在这项横断面观察性研究中，选择了 844 名未使用抗高血压、降脂和抗血小板药物的参与者。根据临床血压测量和动态血压监测结果将受试者分为正常血压（NT）组、WCHT组、隐匿性高血压（MHT）组和持续性高血压（SHT）组。进行冠状动脉造影和动态心电图以确定参与者的 CAS 和心律失常状态。冠状动脉造影显示 556 名 CAS 患者和 288 名参与者冠状动脉正常。卡方检验显示，MHT 和 SHT 组 CAS 发生率高于 NT 组，而 WCHT 组无明显变化（ P = 0.003、P < 0.001、P = 0.119）。采用Gensini评分的对数来比较各组之间的CAS程度。多元线性回归分析显示，WCHT、MHT、SHT 组 CAS 程度高于 NT 组（ P < 0.05）。WCHT和SHT组频繁房性早搏、房性心动过速和室性心律失常的发生率显着高于NT组，而MHT组仅观察到室性心律失常改变。本研究发现WCHT等高血压表型与CAS和心律失常密切相关。
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