The development of a unified and straightforward method for the synthesis of ɤ-alkynylated ketones, esters, and amides is an unmet challenge. Here we report a general and practical protocol to access ɤ-alkynylated esters, ketones, and amides with diverse substitution patterns enabled by dual-catalyzed spontaneous formation of C_sp3–sp3 and C_sp3–sp bond from alkenes at room temperature. This directing-group-free strategy is operationally simple, and allows for the straightforward introduction of an alkynyl group onto ɤ-position of carbonyl group along with the streamlined skeleton assembly, providing a unified protocol to synthesize various ɤ-alkynylated esters, acids, amides, ketones, and aldehydes, from readily available starting materials with excellent functional group compatibility.

统一和直接的方法来合成β-炔基化的酮，酯和酰胺是一项尚未解决的挑战。在这里，我们报告了一种通用且实用的方案，可在室温下通过烯烃双键自发形成C _{sp3 – sp3}和C _{sp3 – sp}键，从而获得具有多种取代方式的ɤ-炔基化酯，酮和酰胺。这种无导向基团的策略操作简单，允许将炔基直接引入羰基的ɤ位以及流线型骨架组装，从而提供了一个统一的协议来合成各种ɤ-炔基化的酯，酸，酰胺，酮和醛，是由易于获得的原料制成，具有出色的官能团相容性。