Transposon silencing requires the histone methyltransferase SETDB1. In this issue of EMBO Reports, Tsusaka et al [1] and Osumi et al [2] illustrate how the cofactor ATF7IP and its fly homolog Windei (Wde) regulate the methyltransferase function of SETDB1 through its nuclear licensing. The new insight gained from these two articles will shift how we think about epigenetic regulation and its multiple layers of control.

中文翻译：

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沉默转座子的核许可证。


转座子沉默需要组蛋白甲基转移酶 SETDB1。在本期 EMBO 报告中，Tsusaka 等人 [1] 和 Osumi 等人 [2] 阐述了辅因子 ATF7IP 及其蝇同源物 Windei (Wde) 如何通过其核许可来调节 SETDB1 的甲基转移酶功能。从这两篇文章中获得的新见解将改变我们对表观遗传调控及其多层控制的看法。