There is a paucity of information on associations between specific types of physical activity and fracture risk at different sites in otherwise healthy postmenopausal women. Therefore, we examined risk of fracture at seven different sites associated with seven different types of physical activity in the population-based prospective UK Million Women Study. A total of 371,279 postmenopausal women (mean age 59.8 years), rating their health as good or excellent and reporting participation in walking, cycling, gardening, doing housework, yoga, dance, and sports club activities, were followed for site-specific incident fracture through record linkage to national databases on day-case and overnight hospital admissions. Cox regression yielded adjusted relative risks (RRs) and, because of the large number of statistical tests done, 99% confidence intervals (CIs) for fracture at seven different sites in relation to seven different physical activities. During an average follow-up of 12 years, numbers with a first site-specific fracture were as follows: humerus (2341), forearm (1238), wrist (7358), hip (4354), femur (not neck) (617), lower leg (1184), and ankle (3629). For upper limb fractures there was significant heterogeneity across the seven activity types (test for heterogeneity p = 0.004), with gardening more than 1 hour/week associated with a lower risk (RR = 0.91; 99% CI, 0.86 to 0.96; p < 0.0001), whereas cycling more than 1 hour/week was associated with an increased risk (RR = 1.11; 99% CI, 1.00 to 1.23; p = 0.008). For fractures of the lower limb (including hip) there was no significant heterogeneity by type of activity, with significant approximately 5% to 15% reductions in risk associated with most activities, except cycling. For hip fractures, there was no significant heterogeneity by type of activity, but with significant 15% to 20% reductions in risk associated with walking for 1 hour/day and participating in yoga and sporting activities. Physical activity is a modifiable risk factor for fracture, but the effects differ between different types of activities and different fracture sites. © 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

中文翻译：

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七种不同类型的体力活动与健康绝经后英国女性七个部位骨折发生率之间的关联。


关于特定类型的体力活动与健康绝经后女性不同部位骨折风险之间关系的信息很少。因此，我们在基于人群的前瞻性英国百万女性研究中检查了与七种不同类型的身体活动相关的七个不同部位的骨折风险。共有 371,279 名绝经后女性（平均年龄 59.8 岁）的健康状况为良好或优秀，并报告参与步行、骑自行车、园艺、做家务、瑜伽、舞蹈和体育俱乐部活动，并对特定部位骨折事件进行了跟踪调查通过与国家数据库的日间病例和夜间入院记录连接。 Cox 回归得出调整后的相对风险 (RR)，并且由于进行了大量的统计测试，与七种不同的身体活动相关的七个不同部位的骨折的 99% 置信区间 (CI)。在平均 12 年的随访期间，首次发生特定部位骨折的人数如下：肱骨（2341）、前臂（1238）、手腕（7358）、髋部（4354）、股骨（非颈部）（617） 、小腿(1184)和脚踝(3629)。对于上肢骨折，七种活动类型之间存在显着异质性（异质性检验 p = 0.004），每周从事园艺超过 1 小时与较低风险相关（RR = 0.91；99% CI，0.86 至 0.96；p % 3C 0.0001），而每周骑自行车超过 1 小时与风险增加相关（RR = 1.11；99% CI，1.00 至 1.23；p = 0.008）。对于下肢（包括髋部）骨折，不同活动类型没有显着异质性，除骑自行车外，与大多数活动相关的风险显着降低约 5% 至 15%。 对于髋部骨折，不同活动类型没有显着异质性，但每天步行 1 小时以及参加瑜伽和体育活动可显着降低 15% 至 20% 的风险。体力活动是骨折的一个可改变的危险因素，但不同类型的活动和不同骨折部位的影响不同。 © 2019 作者。美国骨与矿物质研究学会出版的《骨与矿物质研究杂志》。