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Bactericidal effect of pyridine-2-thiol 1-oxide sodium salt and its complex with iron against resistant clinical isolates of Mycobacterium tuberculosis.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-10-16 , DOI: 10.1038/s41429-019-0243-3 Debora L Campos 1 , Ignacio Machado 2 , Camila M Ribeiro 1 , Dinorah Gambino 3 , Fernando R Pavan 1
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-10-16 , DOI: 10.1038/s41429-019-0243-3 Debora L Campos 1 , Ignacio Machado 2 , Camila M Ribeiro 1 , Dinorah Gambino 3 , Fernando R Pavan 1
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The objective of this study was to determine the activity of pyridine-2-thiol 1-oxide sodium salt (Na mpo) and its complex with iron [Fe(mpo)3] against Mycobacterium tuberculosis. The compounds were tested against a standard strain of M. tuberculosis H37Rv (ATCC 27294), with minimal inhibitory concentrations (MIC90) of 7.20 and 1.07 μM to Na mpo and [Fe(mpo)3], respectively, and against three clinical isolates with different genotypic profiles, with MIC values ranging from 0.74 to 6.52 and 0.30 to 2.25 μM to Na mpo and [Fe(mpo)3], respectively. [Fe(mpo)3] was more effective against susceptible strains but both compounds were effective in inhibiting MDR and XDR-TB clinical strains. The profile activity was determined through the methodology of a time-kill curve against standard and clinical strains of M. tuberculosis. Time-kill studies indicated that Na mpo had an early bactericidal activity against H37Rv and clinical isolates, with sterilizing effects observed in 5 and 7 days, respectively, at its MIC90. The anti MDR and XDR-M. tuberculosis activity and bactericidal effect of Na mpo and [Fe(mpo)3] demonstrate their potential as new compounds for the treatment of tuberculosis.
中文翻译：
吡啶-2-硫醇1-氧化物钠盐及其与铁的复合物对结核分枝杆菌耐药性临床分离株的杀菌作用。
这项研究的目的是确定吡啶-2-硫醇1-氧化物钠盐（Na mpo）及其与铁[Fe（mpo）3]的配合物对结核分枝杆菌的活性。测试了这些化合物对结核分枝杆菌H37Rv（ATCC 27294）的标准菌株的影响，对Na mpo和[Fe（mpo）3]的最小抑菌浓度（MIC90）分别为7.20和1.07μM，并且对三种临床分离株分别为到Na mpo和[Fe（mpo）3]的MIC值分别为0.74至6.52和0.30至2.25μM。[Fe（mpo）3]对敏感菌株更有效，但两种化合物均能有效抑制MDR和XDR-TB临床菌株。通过针对结核分枝杆菌的标准菌株和临床菌株的时间杀灭曲线的方法确定概况活性。时间杀灭研究表明，Na mpo对H37Rv和临床分离株具有早期杀菌活性，分别在其MIC90的第5天和第7天观察到了杀菌作用。抗MDR和XDR-M。Na mpo和[Fe（mpo）3]的结核菌活性和杀菌作用证明了它们作为治疗结核病的新化合物的潜力。
更新日期：2020-01-17
中文翻译：
吡啶-2-硫醇1-氧化物钠盐及其与铁的复合物对结核分枝杆菌耐药性临床分离株的杀菌作用。
这项研究的目的是确定吡啶-2-硫醇1-氧化物钠盐（Na mpo）及其与铁[Fe（mpo）3]的配合物对结核分枝杆菌的活性。测试了这些化合物对结核分枝杆菌H37Rv（ATCC 27294）的标准菌株的影响，对Na mpo和[Fe（mpo）3]的最小抑菌浓度（MIC90）分别为7.20和1.07μM，并且对三种临床分离株分别为到Na mpo和[Fe（mpo）3]的MIC值分别为0.74至6.52和0.30至2.25μM。[Fe（mpo）3]对敏感菌株更有效，但两种化合物均能有效抑制MDR和XDR-TB临床菌株。通过针对结核分枝杆菌的标准菌株和临床菌株的时间杀灭曲线的方法确定概况活性。时间杀灭研究表明，Na mpo对H37Rv和临床分离株具有早期杀菌活性，分别在其MIC90的第5天和第7天观察到了杀菌作用。抗MDR和XDR-M。Na mpo和[Fe（mpo）3]的结核菌活性和杀菌作用证明了它们作为治疗结核病的新化合物的潜力。
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