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A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2019-10-15 , DOI: 10.1038/s41372-019-0510-y
Amy M Padula 1 , Catherine Monk 2 , Patricia A Brennan 3 , Ann Borders 4 , Emily S Barrett 5 , Cindy T McEvoy 6 , Sophie Foss 2 , Preeya Desai 2 , Akram Alshawabkeh 7 , Renee Wurth 7 , Carolyn Salafia 8 , Raina Fichorova 9 , Julia Varshavsky 1 , Amii Kress 10 , Tracey J Woodruff 1 , Rachel Morello-Frosch 11 ,
Affiliation  

Exposures to environmental chemicals and psychosocial stressors during pregnancy have been individually associated with adverse perinatal outcomes related to birthweight and gestational age, but are not often considered in combination. We review types of psychosocial stressors and instruments used to assess them and classes of environmental chemical exposures that are known to adversely impact perinatal outcomes, and identify studies relevant studies. We discuss the National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) program that has combined existing longitudinal cohorts that include more than 50,000 children across the U.S. We describe future opportunities for investigators to use this important new resource for addressing relevant and critical research questions to maternal health. Of the 84 cohorts in ECHO, 38 collected data on environmental chemicals and psychosocial stressors and perinatal outcomes. The diverse ECHO pregnancy cohorts provide capacity to compare regions with distinct place-based environmental and social stressors.

中文翻译:


对母亲产前接触环境化学物质和社会心理压力源的回顾——对 ECHO 计划围产期结果研究的影响。



怀孕期间接触环境化学物质和社会心理压力源与出生体重和胎龄相关的不良围产期结局单独相关,但通常不将其综合考虑。我们回顾了社会心理压力源的类型和用于评估它们的工具以及已知会对围产期结局产生不利影响的环境化学物质暴露类别,并确定相关研究。我们讨论了美国国立卫生研究院的环境对儿童健康结果的影响 (ECHO) 计划,该计划结合了现有的纵向队列,其中包括全美 50,000 多名儿童。我们描述了研究人员使用这一重要的新资源来开展相关和关键研究的未来机会孕产妇健康问题。在 ECHO 的 84 个队列中,38 个队列收集了有关环境化学物质、社会心理压力源和围产期结局的数据。多样化的 ECHO 妊娠队列提供了比较具有不同地点环境和社会压力源的区域的能力。
更新日期:2019-10-16
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