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PRC2-mediated MHC-I silencing drives immune evasion.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2019-12-01 , DOI: 10.1038/s41568-019-0219-4
Conor A Bradley 1
Affiliation  

Burr et al. report an evolutionarily conserved, tumour-intrinsic role for Polycomb repressive complex 2 (PRC2) in the epigenetic silencing of MHC class I antigen presentation pathway genes, illustrating that cancer cells can co-opt the immunomodulatory functions of PRC2 to evade immune surveillance.

中文翻译:

PRC2 介导的 MHC-I 沉默驱动免疫逃避。

伯尔等人。报告了 Polycomb 抑制复合物 2 (PRC2) 在 MHC I 类抗原呈递途径基因的表观遗传沉默中的进化上保守的肿瘤内在作用,说明癌细胞可以利用 PRC2 的免疫调节功能来逃避免疫监视。
更新日期:2019-10-15
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