The oxygen reduction response (ORR) shows sluggish kinetics on cathode surface, which welcomes a noteworthy commitment to the efficiency loss of the fuel cell devices. The advancements in the designing and developments of the competent electrocatalysts for ORR suggest that the macrocycles is the class of versatile materials for the rapid ORR. The hypothetical investigations and trial results specify that the ORR activity of MN₄-macrocycles (M = Mn, Fe and Co) can be regulated by directing its M^II/III formal potential through proper substitution on the macrocyclic framework and metal center. In this work, we tended to the principal dialog beginning from the fundamental chemistry of fuel cell, ORR, macrocycles, dioxygen, and metal–dioxygen (M–O₂) bond communication, as the establishment of this survey. At that point, the emphasis on the comprehensive designs and developments on current macrocycles-based nanocomposites for ORR and the molecular understanding of macrocycles-based ORR descriptors, was considered as the core of this survey. The significance of this survey lies in objective planning the electrocatalysts beginning from the most essential normal for the electronic auxiliary designing to an increasingly reasonable dimension of nanofabrication.

氧还原反应（ORR）在阴极表面显示出缓慢的动力学，这是对燃料电池装置效率损失的值得关注的承诺。用于ORR的有效电催化剂的设计和开发方面的进展表明，大环化合物是用于快速ORR的通用材料。假设的研究和试验结果表明，MN _4-大环（M = Mn，Fe和Co）的ORR活性可以通过在大环骨架和金属中心上进行适当的取代来指导其MII ^{/ III}形式势来调节。在这项工作中，我们倾向于从燃料电池，ORR，大环，双氧和金属双氧（M–O ₂）债券沟通，以此作为本次调查的建立。那时，对当前基于大环的ORR纳米复合材料的全面设计和开发以及对基于大环的ORR描述符的分子理解的重点被认为是本次调查的核心。这项调查的意义在于，从电子辅助设计的最基本标准到纳米制造的日益合理的尺寸，从客观上规划电催化剂。