As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are attracting significant interest, particularly in relation to identification of peptides displaying potent but selective effects. Much less focus has been placed on delivery systems for AMPs, despite AMPs suffering from delivery challenges related to their size, cationicity, and amphiphilicity. Inorganic nanoparticles may provide opportunities for controlling peptide release, reducing infection-related AMP degradation, or increasing bioavailability. Numerous such nanomaterials display potent and triggerable antimicrobial effects on their own. When combined with AMPs, combinatorial and synergistic effects in relation to the behavior of such mixed systems as antimicrobials have been observed. The mechanistic origin of these effects are poorly understood that at present, however, precluding rational design of mixed nanoparticle/AMP antimicrobials and nanoparticulate delivery systems for AMPs. Here, the area of membrane interactions and antimicrobial effects of inorganic nanomaterials are briefly outlined, in combination with AMPs.

由于越来越多的细菌产生对抗生素的抗性，所以抗菌肽（AMP）引起了人们的极大兴趣，特别是在鉴定具有有效但选择性作用的肽方面。尽管AMP受到与尺寸，阳离子和两亲性有关的递送挑战的困扰，但对AMP递送系统的关注却很少。无机纳米粒子可能提供控制肽​​释放，减少感染相关AMP降解或提高生物利用度的机会。许多这样的纳米材料本身显示出有效的和可触发的抗菌作用。当与AMP组合时，已经观察到与诸如抗菌剂的混合系统的行为有关的组合和协同作用。目前，人们对这些作用的机理起源了解甚少，但目前尚无法合理设计AMPs的混合纳米颗粒/ AMP抗菌剂和纳米颗粒递送系统。在此，结合AMP简要概述了无机纳米材料的膜相互作用和抗菌作用区域。