Mechanochemistry for the production of a hybrid salt used in the treatment of malaria†,Green Chemistry

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Mechanochemistry for the production of a hybrid salt used in the treatment of malaria†
Green Chemistry ( IF 9.3 ) Pub Date : 2019-10-14 , DOI: 10.1039/c9gc02478f
Vânia M. do Prado _{1,

2,

3,

4} , Thiago B. de Queiroz _{1,

2,

3,

4} , Paula M. Sá _{4,

5,

6,

7} , Rafael C. Seiceira _{4,

6,

7,

8} , Nubia Boechat _{4,

5,

6,

7} , Fabio F. Ferreira _{1,

2,

3,

4}

Affiliation

Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents in chemical reactions and greener and more efficient synthetic solutions. In this paper we obtain, via mechanochemistry, a hybrid salt, named MEFAS, derived from two antimalarial molecules – mefloquine and artesunate. We demonstrate, using a simple experimental procedure, how the catalytic amount of liquid present during mechanochemical reactions is decisive to obtain MEFAS. Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) data indicate that liquid-assisted mechanochemical reactions are promising in the formation of the hybrid salt, which is formed via a hydrogen interaction of the carboxylate group of the artesunate molecule with the piperidine group of mefloquine.

中文翻译：

机械化学生产用于治疗疟疾的杂种盐†

机械化学是指由涉及固体的机械能引起的化学反应。与溶液相合成相比，该方法具有多个优势，例如，最大程度地减少了化学反应中对大量溶剂的需求以及更绿色，更高效的合成溶液。在本文中，我们通过机械化学方法获得了一种名为MEFAS的杂化盐，该杂化盐衍生自两种抗疟疾分子-甲氟喹和青蒿琥酯。我们证明，使用简单的实验程序，在机械化学反应过程中存在的催化量的液体如何对获得MEFAS起决定性作用。傅立叶变换红外光谱（FTIR）和核磁共振（NMR）数据表明，液体辅助的机械化学反应在杂化盐的形成中很有前途，杂化盐的形成通过青蒿琥酯分子的羧酸酯基团与甲氟喹的哌啶基团之间的氢相互作用。

更新日期：2020-01-02

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