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Low serum IgA and airway injury in World Trade Center-exposed firefighters: a 17-year longitudinal study
Thorax ( IF 9.0 ) Pub Date : 2019-10-14 , DOI: 10.1136/thoraxjnl-2019-213715
Barbara Putman 1, 2 , Lies Lahousse 2 , Rachel Zeig-Owens 3, 4 , Ankura Singh 3, 5 , Charles B Hall 4 , Yang Liu 3, 5 , Theresa Schwartz 3, 5 , David Goldfarb 3, 5 , Mayris P Webber 3, 4 , David J Prezant 3, 5 , Michael D Weiden 3, 6
Affiliation  

Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.

中文翻译:


暴露于世贸中心的消防员的低血清 IgA 和气道损伤:一项为期 17 年的纵向研究



血清 IgA ≤70 mg/dL(低 IgA)与慢性阻塞性肺病的恶化有关。低 IgA 与纵向肺功能的关系尚不清楚。这项研究纳入了 917 名接触过世贸中心 (WTC) 的消防员,他们在 2001 年 9 月至 2018 年 9 月期间测量了纵向肺量计,并在 2001 年 10 月至 2002 年 3 月期间测量了 IgA。与 IgA >70 mg/dL 相比,低 IgA 与较低的用力相关。 2001 年 9 月 11 日之后的一年中预测的 1 秒呼气量 (FEV1) %(94.1% vs 98.6%,p<0.001),FEV1/FVC <0.70 的风险增加(HR 3.8,95% CI 1.6 至 8.8)并且增加抗生素治疗(22.5/100 vs 11.6/100 人年,p=0.002)。 WTC 暴露后,早期 IgA ≤70 mg/dL 与肺功能恶化和抗生素治疗增加相关。
更新日期:2019-10-14
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