INTRODUCTION EUS-guided gallbladder drainage (EUS-GBD) is an emerging option for acute cholecystitis in non-surgical candidates. Combining ERCP for CBD stones with EUS-GBD in a single-session might become a non-surgical management strategy to address gallstone disease comprehensively in selected patients. METHODS Single-center retrospective cohort study comparing outcomes between EUS-GBD alone (Group A)and single-session ERCP combined with EUS-GBD (Group B). Consecutive patients who underwent EUS-GBD with a lumen-apposing metal stents (LAMS) between June 2011 and August 2018were analyzed. Exclusion criteria were:subjects included in randomized clinical trials, patients who had had ERCP within 5 days of EUS-GBD, patientsin whom ERCP or EUS-GBD were undertaken for salvage of one another, and patients who underwent concurrent EUS-guided biliary drainage. RESULTS One hundred and nine consecutive patients underwent EUS-GBD with LAMS during the study period.Seventy-one patients satisfied the inclusion criteria and 34 patients were in Group A and 37 in Group B. Baseline characteristics were similar in both groups. There were no significant differences in technical (97.1% vs 97.3%; p=0.19) and clinical success rates (88.2% vs 94.6%; p=0.42) of EUS-GBD in Group A versus Group B. The rate of adverse events was similar in both groups, 5 (14.7%) in Group A versus 5 (13.5%) in Group B. CONCLUSIONS Single-session EUS-GBD combined with ERCP hascomparable rates of technical and clinical success to EUS-GBD alone. A combined EUS-GBD and ERCP procedure doesnot appear to increase adverse events and makes comprehensive treatment of gallstone disease by purely endoscopic means possible.

中文翻译：

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EUS 引导下胆囊引流术联合 ERCP 的安全性和有效性

引言 EUS 引导下胆囊引流术 (EUS-GBD) 是非手术患者急性胆囊炎的新兴选择。在一次疗程中将 CBD 结石的 ERCP 与 EUS-GBD 相结合可能成为一种非手术管理策略，以全面解决选定患者的胆结石疾病。方法 单中心回顾性队列研究，比较单独 EUS-GBD（A 组）和单次 ERCP 联合 EUS-GBD（B 组）的结果。分析了 2011 年 6 月至 2018 年 8 月期间连续接受 EUS-GBD 和管腔对位金属支架 (LAMS) 的患者。排除标准是：纳入随机临床试验的受试者，在 EUS-GBD 5 天内进行过 ERCP 的患者，为挽救彼此而进行 ERCP 或 EUS-GBD 的患者，和同时接受 EUS 引导下胆道引流的患者。结果 109 例连续患者在研究期间接受了 EUS-GBD 和 LAMS。71 例患者符合纳入标准，A 组 34 例，B 组 37 例。两组的基线特征相似。EUS-GBD 在 A 组和 B 组中的技术（97.1% 对 97.3%；p=0.19）和临床成功率（88.2% 对 94.6%；p=0.42）没有显着差异。不良事件发生率为两组相似，A 组为 5 (14.7%)，B 组为 5 (13.5%)。 结论 单次 EUS-GBD 联合 ERCP 具有与单独 EUS-GBD 相当的技术和临床成功率。