OBJECTIVES Apheresis has been used as adjunctive treatment of severe falciparum malaria, loiasis and babesiosis. This systematic review aimed to investigate the safety and efficacy of apheresis in the treatment of these conditions. METHODS MEDLINE, PUBMED, EMBASE and CINAHL databases were searched to identify studies published between January 1969 and March 2018 involving patients treated using apheresis for severe falciparum malaria, loiasis or babesiosis. Data extracted included details about the apheresis intervention, populations, study methods and outcomes relating to efficacy and safety. RESULTS A total of 67 publications met the inclusion criteria and were included in the data synthesis, 36 for malaria (70 cases), 17 for babesiosis (22 cases) and 14 for loiasis (34 cases). Publications were case reports, case series, and cohort studies; there were no randomised controlled trials identified. Potential publication bias was considered to be high. CONCLUSIONS Systematic review of the literature suggests that apheresis may be a useful adjunct in the treatment of patients hospitalised for babesiosis, and prior to chemotherapy in loiasis with microfilarial count >8000 parasites/mL. Data does not support the use of apheresis in patients with severe falciparum malaria.

中文翻译：

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血液分离术在传染病治疗中的安全性和有效性：系统评价。

目的剥脱术已被用作严重恶性疟疾，精神病和巴贝西虫病的辅助治疗。该系统评价旨在研究单采血液分离术在这些疾病中的安全性和有效性。方法检索MEDLINE，PUBMED，EMBASE和CINAHL数据库，以鉴定1969年1月至2018年3月发表的涉及使用单采血液分离术治疗严重恶性疟疾，疯牛病或巴贝氏病的患者的研究。提取的数据包括有关血液分离术干预措施，人群，研究方法以及与疗效和安全性有关的结果的详细信息。结果共有67篇符合纳入标准的出版物被纳入数据综合研究，其中疟疾36篇（70例），巴贝西虫病17篇（22例）和精神病14例（34例）。出版物包括病例报告，病例系列和队列研究。没有确定随机对照试验。潜在的出版偏见被认为是很高的。结论对文献的系统评价表明，单采血液分离术可能是治疗住院的贝贝病的患者的辅助手段，并且在化疗前先行微丝计数> 8000寄生虫/ mL的丝虫​​病患者。数据不支持在严重恶性疟疾患者中使用血液分离术。