Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives,Journal of Applied Polymer Science

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Polymeric injectable fillers for cosmetology: Current status, future trends, and regulatory perspectives
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2019-10-13 , DOI: 10.1002/app.48515
Peng Zhao ₁ , Wanlu Zhao ₂ , Kai Zhang _{2,

3} , Hai Lin ₂ , Xingdong Zhang _{2,

3}

Affiliation

Injectable fillers have become a vital part of cosmetology. A wide variety of injectable fillers are developed for either correction of facial wrinkles and folds or facial contouring. As the most popular filler products, polymeric injectable fillers represent a class of the most common implantable medical devices. This review is intended to not only present current filler products, but also share perspectives of future trends, development processes, and regulatory considerations for the next generation of fillers. First, currently approved polymeric injectable fillers are described in detail. Second, future trends of polymeric injectable fillers are discussed. Fillers based on the emerging technologies in tissue engineering and regenerative medicine with stimuli‐responsive or tunable properties, as well as device/drug combination products, are promising candidates. Third, fillers for cosmetology are different from traditionally recognized medical devices. As a result, the target population of such fillers is different from that of other implantable devices, leading to different user needs that impact their development processes. Last, product applications, regulatory requirements, device evaluation, characteristics, and difficulties for regulating filler products for minimally invasive cosmetology are reviewed. Both regulatory science and scientific supervision are needed for polymeric injectable fillers which are facing great opportunities as well as challenges. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48515.

中文翻译：

美容用高分子可注射填充剂：现状，未来趋势和监管观点

可注射填充剂已成为美容的重要组成部分。开发了多种可注射填充剂，用于矫正面部皱纹和皱纹或面部轮廓。作为最流行的填充产品，聚合物可注射填充剂代表一类最常见的可植入医疗设备。这篇综述不仅旨在介绍当前的填料产品，而且还分享了下一代填料的未来趋势，开发过程和监管方面的观点。首先，详细描述当前批准的聚合物可注射填充剂。其次，讨论了聚合物可注射填料的未来趋势。基于组织工程和再生医学中新兴技术的具有刺激响应性或可调性的填充剂，以及器械/药物组合产品，是有前途的候选人。第三，用于美容的填充物不同于传统上公认的医疗设备。结果，此类填充物的目标人群与其他可植入设备的人群不同，从而导致影响其开发过程的不同用户需求。最后，对产品应用，法规要求，设备评估，特性以及针对微创美容的填充产品法规进行了审查。面临着巨大机遇和挑战的聚合物可注射填充剂既需要监管科学，也需要科学监督。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学此类填充物的目标人群与其他可植入设备的人群不同，从而导致影响其开发过程的不同用户需求。最后，对产品应用，法规要求，设备评估，特性以及针对微创美容的填充产品法规进行了审查。面临着巨大机遇和挑战的聚合物可注射填充剂既需要监管科学，也需要科学监督。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学此类填充物的目标人群与其他可植入设备的人群不同，从而导致影响其开发过程的不同用户需求。最后，对产品应用，法规要求，设备评估，特性以及针对微创美容的填充产品法规进行了审查。面临着巨大机遇和挑战的聚合物可注射填充剂既需要监管科学，也需要科学监督。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学面临着巨大机遇和挑战的聚合物可注射填充剂既需要监管科学，也需要科学监督。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学面临着巨大机遇和挑战的聚合物可注射填充剂既需要监管科学，也需要科学监督。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学2020，137，48515。

更新日期：2020-03-26

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