Mechanisms of acquired resistance to ALK inhibition therapy in neuroblastoma have not yet been elucidated. In a recent issue of Nature, Debruyne et al. demonstrate that resistant MYCN-amplified ALK-mutated neuroblastoma cells overexpress BORIS, resulting in wide-ranging changes in chromatin interaction and transcriptional reprogramming.

中文翻译：

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投掷循环：唤醒BORIS以逃避ALK抑制疗法。

尚未阐明神经母细胞瘤中获得性的对ALK抑制治疗的抗性机制。在《自然》杂志的最新一期中，Debruyne等人。证明抗性MYCN扩增的ALK突变的神经母细胞瘤细胞过表达BORIS，导致染色质相互作用和转录重编程发生广泛变化。