The transcriptome of prostate cancer is highly heterogeneous, with noncoding transcripts being essential players. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two unique classes of noncoding RNA drawing increasing attention. Biologically, they have intriguing properties with important regulatory functions. Clinically, they present as promising biomarkers and therapeutic targets. Recent advancements in technologies have opened up new directions for noncoding RNA research, which include RNA-protein interaction, RNA secondary structure, and spatial transcriptomics. Furthermore, recent work has also evaluated the clinical applications of these noncoding RNAs in noninvasive liquid biopsy and RNA-based therapies. In this review, we summarize recent findings on lncRNAs and circRNAs in prostate cancer, discuss their clinical utilities, and highlight these exciting areas of research.

中文翻译：

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前列腺癌中非编码RNA的前景。

前列腺癌的转录组是高度异质的，非编码转录组是必不可少的。长的非编码RNA（lncRNA）和环状RNA（circRNA）是引起人们关注的两类独特的非编码RNA。从生物学上讲，它们具有重要的调节功能的有趣特性。在临床上，它们呈现为有前途的生物标志物和治疗靶标。技术的最新进展为非编码RNA研究开辟了新的方向，包括RNA蛋白质相互作用，RNA二级结构和空间转录组学。此外，最近的工作还评估了这些非编码RNA在无创液体活检和基于RNA的疗法中的临床应用。在这篇综述中，我们总结了有关前列腺癌中lncRNA和circRNA的最新发现，并讨论了它们的临床用途，