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Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-10-11 , DOI: 10.1038/s41429-019-0246-0
Junjing Jiao 1 , Jiayi Du 1 , Andri Frediansyah 1, 2 , Ghazaleh Jahanshah 1 , Harald Gross 1
Affiliation  

Within the framework of our effort to discover new bioactive metabolites from Gram-negative bacteria, trinickiabactin (1) was isolated from the plant pathogenic strain Trinickia caryophylli DSM 50341. Whole genome sequencing allowed the identification of its biosynthetic gene cluster. The structure of 1 bears a rare diazeniumdiolate ligand system and was elucidated by a combination of NMR- and MS-spectroscopic techniques and bioinformatics. Trinickiabactin was found to be antibacterial toward several Gram-negative bacteria (MIC values ranged from 3.5 to 34.0 µg ml−1).



中文翻译:

植物病原菌卡尼叶氏菌Trinickiabactin的结构解析和生物合成位点。

在我们从革兰氏阴性细菌中发现新的生物活性代谢物的努力框架内,从植物致病性菌株Trinickia caryophylli DSM 50341中分离出了三尼克菌素(1)。全基因组测序可以鉴定其生物合成基因簇。1的结构带有稀有的二醇二氮烯鎓配体系统,并通过NMR和MS光谱技术与生物信息学的结合加以阐明。发现三尼克菌素对几种革兰氏阴性细菌具有抗菌作用(MIC值为3.5至34.0 µg ml -1)。

更新日期:2020-01-16
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