Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli.,The Journal of Antibiotics

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Structure elucidation and biosynthetic locus of trinickiabactin from the plant pathogenic bacterium Trinickia caryophylli.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-10-11 , DOI: 10.1038/s41429-019-0246-0
Junjing Jiao ₁ , Jiayi Du ₁ , Andri Frediansyah _{1,

2} , Ghazaleh Jahanshah ₁ , Harald Gross ₁

Affiliation

Within the framework of our effort to discover new bioactive metabolites from Gram-negative bacteria, trinickiabactin (1) was isolated from the plant pathogenic strain Trinickia caryophylli DSM 50341. Whole genome sequencing allowed the identification of its biosynthetic gene cluster. The structure of 1 bears a rare diazeniumdiolate ligand system and was elucidated by a combination of NMR- and MS-spectroscopic techniques and bioinformatics. Trinickiabactin was found to be antibacterial toward several Gram-negative bacteria (MIC values ranged from 3.5 to 34.0 µg ml⁻¹).

中文翻译：

植物病原菌卡尼叶氏菌Trinickiabactin的结构解析和生物合成位点。

在我们从革兰氏阴性细菌中发现新的生物活性代谢物的努力框架内，从植物致病性菌株Trinickia caryophylli DSM 50341中分离出了三尼克菌素（1）。全基因组测序可以鉴定其生物合成基因簇。1的结构带有稀有的二醇二氮烯鎓配体系统，并通过NMR和MS光谱技术与生物信息学的结合加以阐明。发现三尼克菌素对几种革兰氏阴性细菌具有抗菌作用（MIC值为3.5至34.0 µg ml ^-1）。

更新日期：2020-01-16

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