Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step.,Advanced Healthcare Materials

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Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-10-11 , DOI: 10.1002/adhm.201900775
Marleen Kristen _{1,

2} , Madison J Ainsworth _{1,

2} , Nino Chirico _{1,

3} , Casper F T van der Ven _{1,

3} , Pieter A Doevendans _{3,

4} , Joost P G Sluijter _{1,

3} , Jos Malda _{1,

2,

5} , Alain van Mil _{1,

3,

4} , Miguel Castilho _{1,

2,

6}

Affiliation

Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

中文翻译：

用于治愈心灵的纤维支架图案：3D 组织带来下一步。

心力衰竭（HF）是全世界死亡的主要原因。导致心力衰竭的最常见疾病是冠状动脉疾病、心肌梗死、瓣膜疾病、高血压和心肌病。由于心脏的再生能力有限，目前唯一的治疗方法是心脏移植。因此，非常需要开发新的再生策略来修复受损的心肌、更换受损的瓣膜和治疗闭塞的冠状动脉。制造技术的最新进展已经实现了具有高度结构控制的 3D 纤维支架的精确制造，可以支持和引导新组织的生长，为人类心脏的修复开辟了令人兴奋的新途径。这篇综述讨论了心脏组织工程（cTE）纤维图案制造技术的最新研究领域的最新进展，以及这些技术在多大程度上可以满足高度组织化和结构化的心脏组织的要求。此外，还介绍了这些新型光纤图案技术、设计以及推进 cTE 的适用性的未来方向。

更新日期：2020-01-08

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